Flashcards in Miscellaneous Antimicrobial Agents And Urinary Antiseptics Deck (16):
Mention 2 nitroimidazoles.
What is the mechanism of action of nitroimidazoles?
Disrupt electron transport.
What are the effects of nitroimidazoles?
Bactericidal vs anaerobic bacteria and certain Protozoa.
What are the clinical applications of nitroimidazoles?
1. Anaerobic bacterial infections.
2. C.difficile colitis
What are the pharmacokinetics of nitroimidazoles?
Oral/IV + hepatic clearance.
Tinidazole --> longer half-life.
What are the toxicities of nitroimidazoles?
1. GI upsets
2. Metallic taste
4. Disulfiram-like interaction with alcohol
Mention two main urinary antiseptics.
2. Methenamine salts
What is the mechanism of action of urinary antiseptics?
Nitrofurantoin --> not identified.
Methenamine --> forms formaldehyde in urine.
What are the effects of urinary antiseptics?
Bactericidal or bacteriostatic.
What are the clinical applications of urinary antiseptics?
1. Simple urinary tract infections and prophylaxis.
2. Methenamine is used for suppression in UT infections.
What are the pharmacokinetics of urinary antiseptics?
2. Low blood levels
3. High urine levels
What are the possible toxicities of urinary antiseptics?
1. GI upset
2. Neuropathy (Nitrofurantoin)
What is the mechanism of action of fidaxomicin?
Inhibits bacterial RNA polymerase.
What are the effects of fidaxomicin?
What are the clinical applications of fidaxomicin?