Miscellaneous Drugs & Drug Interactions Flashcards Preview

Pharmacology > Miscellaneous Drugs & Drug Interactions > Flashcards

Flashcards in Miscellaneous Drugs & Drug Interactions Deck (44):
1

Name three commonly used dyes and contrast media

Methylene blue
Indigo carmine
Fluoroscein

2

Methylene Blue is used for

evaluation of urine clearance time
to identify where ureters enter the bladder
treat methemoglobinemia

3

Large doses of M. blue may cause

Nausea, abdominal pain, h/a, METHEMOGLOBINEMIA

4

*IV bolus of M.Blue is associated with

TRANSIENT HYPOTENSION and False Sp02 reduction (dye changes blood color)

5

Never give M.Blue

SQ, Intrathecally

6

Indigo Carmine is used to

evaluate urine clearance time
to identify where ureters enter bladder

7

I. Carmine is associated with

slight hypertension

8

I. Carmine is prepared in a

0.8% solution in 5 mL ampules

9

M. Blue is prepared in a

1% solution in 10 mL ampules

10

Fluoroscein is used for

diagnostic angiography, or angioscopy of the fundus and iris vasculature

11

Fluoroscein should not be

injected intrathecally

12

Fluoroscein transiently causes skin and urine to turne

yellowish

13

True or False, Fluroscein can cause allergic rxn

True

*caution in asthmatics

14

The incidence of adverse drug interaction increases as the ------ of concurrently administered drugs increases

Number

15

Thiopental (pH 10.5) precipitates when mixed with

Opioids (pH 3-4)

16

Heparin (acidic) is neutralized by

Protamine (basic)

17

Local anesthetics mixed with ------ prolongs the DOA of the LA

epinephrine

18

Barbiturates are displaced from their protein binding site by ------- leading to an increase in the barbiturate effect

Contrast media

19

Hepatic Cytochrome P-450 system is INDUCED by

Barbiturates/ Phenytoin

20

** Pseudocholinesterase is inhibited by -------, and thereby prolongs the DOA of -------

Echothiphate (eye drop), Succinylcholine

21

Phenobarital's excretion is enhanced if the urine is alkalinized by

Sodium bicarbonate

22

Alveolar elimination of volatile anesthetic agents are prolonged with what ventilatory depressant drug

Opioids

23

Naloxone inhibits the acitivity of

Opioids

24

*Magnesium increases the DOA of

Non-depolorizing muscle relaxants

25

Chlorpromazine (thorazine) combined with -----, produces profound hypotension

halogenated agents

26

Albuterol combined with -------- increase risk of dysrthythmias and hypertension

halogenated agents

27

ANTIcholenesterases have what effect on the heart rate

SEVERE BRADYCARDIA

28

Lidocaine can induce ----- and decrease -----, and------.

induce and maintain anesthesia
decrease stress response during intubation
decrease MAC, if plasma levels maintained via infusion

29

Isoflurane sensitize myocardium to

catecholamines

*epinephrine must be limited to 3.5 mcg/kg/10-minute period when given with Isoflurane

30

MAO Inhibitors block metabolism of

Catecholamines

Nardil, Parnate, Marplan

31

MOAIs should be stopped how long before surgery

2 weeks

32

MAOIs have a synergestic effects with

halogenated agents, opioids, barbiturates

33

What opioid is STRICTLY CONTRAINDICATED with MAOIs

Meperidine>>>CNS excitation, hyperpyrexia, DEATH

34

Tricylclc Antidepressants block reuptake of

Norephinephrine>>>>Profound Tachy, Hypertension

Elavil
Pamelor
Tofanil
Sinequan

35

TCA should be continued until

the day of surgery

36

** Pancuronium and cause ------when given with TCA

DYSRHYTHMIAS

37

Cimetidine inhibits

P-450 system

38

Cimetidine ----hepatic blood flow

decreases and thereby decreases the rate of biotransformation

39

Acute alcohol intoxication -------MAC

decreases

40

Chronic alcohol abuse------MAC

increases

41

Cocaine -------reuptake of ------

Inhibits, reuptake of norepinephrine

42

Key treatment goal of patient on cocaine

Avoid SNS stimulation due to exaggerated responses that can be life threatening.

43

What NMBA should be avoid in cocaine users

Pancuronium

44

All halogenated agents produce what effect of the heart

Myocardial depression