Mixed Block Notes 12 Flashcards Preview

Uworld > Mixed Block Notes 12 > Flashcards

Flashcards in Mixed Block Notes 12 Deck (76):
1

Nomal post-void residual volume

50cc

2

Oxybutynin

Anti-muscarinic for urge incontinence

3

Histology of Hep B vs C

B = Ballooning, Necrosis, Portal inflammation, GROUND GLASS; C = Lymphoid aggregates w/in portal tracts, Focal areas of macrovesicular steatosis

4

Most common meds that cause ED other than SSRIs

Clonidine, Methyldopa, BB's

5

COMT inhibitors vs Carbidopa

Both peripheral work peripherally; Carbidopa on DOPA decarboxylase

6

Entacapone vs Tolcapone

Entacapone is peripheral only (can't Enter the CNS); Tolcapone associated with haptotoxicity

7

MOA of Ropinerole

DA agonist

8

Carrier vs Channel proteins

Carrier proteins undergo conformational changes as substrate is transported

9

Uptake of cholesterol occurs via

Receptor-mediated endocytosis

10

Transport of Glucose by Glut4 is

Carrier-mediated transport (co-transport in GI tract, renal tubule)

11

Blank requirements are lower in adrenal insufficiency

Insulin

12

Chloride in primary adrenal insufficiency

Increased to maintain electroneutrality of extracellular fluid

13

Secondary/Tertiary adrenal insufficency vs primary

Can still release aldosterone in response to AgII --> No electrolyte

14

Isolated hyperkalemia can be caused by

Insulin deficiency; Diet; Cell lysis; B1 antagonists

15

Side effects of Flutamide

Hot flashes, Gynecomastia, Impotence (androgen depletion)

16

GnRH agonists

Leuprolide, Goserelin, Nafarelin, Histrelin

17

Cyproterone MOA

Androgen receptor blocker (like Flutamide)

18

IL-2 is approved for treatment of

RCC, Melanoma

19

Translocation is catalyzed by blank and requires blank

EF2, GTP hydrolysis

20

Type of anemia in beta thal minor

Hypochromic, microcytic

21

Most common cell type in pituitary

Somatotroph

22

How to prevent HSV2 recurrences

Daily treatment with Acyclovir, Valacyclovir, Famciclovir

23

Close contact prophylaxis for Hep A

Ig, Vaccine for high risk

24

Vaginal Adenosis

Glandular metaplasia due to DES --> Clear cell adenocarcinoma

25

Blutn Aortic Injury ocurs most often at

Isthmus (attched to Ligamentum Arteriosum)

26

Fall on outstretched, dorsiflexed hand

Lunate discloation

27

Onset of Otosclerosis

middle age

28

AE's of Ganciclovir

Pancytopenias, Renal

29

Major AE of Zidovudine

BM suppression

30

Foscarnet AE

Electrolytes, Renal

31

AE's common to all NNRTI's

Rash/SJS, Hepatotoxicity

32

MOA of Nitroglycerin

Dilate large veins --> Decr preload

33

Primary site of hormonal regulation of systemic BP

Small arteries and arterioles

34

Control of precapillary sphincters

NE, Epi, Local regulators

35

Rhabditiform Larvae in stool

Strongyloides --> Ivermectin

36

Parasite eggs in stool

Schistosoma mansoni or japonicum --> Praziquantel

37

Proglottids in stool

Tapeworms = Taenia, Diphyllobothrium

38

Trophozoites and Cysts in stool

Protozoa = Giardia lamblia, Entamoeba histolytica

39

Strongyloides infection

Skin penetration --> Alveoli --> Pharynx --> Intestine --> Autoinfection

40

a-Glucosidase inhibitors

Acarbose, Miglitol

41

Th in Cronhn's vs UC

Th1 in Crohn's, Th2 in UC

42

First 5 years of diabetic nephropathy

Glomerular hypertrophy, Increase GFR!

43

Gouty nephropathy

Chronic tubulointerstitial nephritis

44

First line for Wilson's

Penicillamine, Trientene

45

Vitamin store longevity for A, D, Folate, B12

A for 6 months, D for 3 months, Folate for 3 monts, B12 for 3-4 years

46

Storage of water soluble vitamins

All flushed easily except folate and B12

47

Anti-psychotics more likely to cause anti-cholinergic effects

Traditional low-potency (eg chlorpromazine, thiordazine)

48

Alleviation of negative symptoms of schizophrenia is thought to be due to

Inhibition of 5-HT2a (atypical anti-psychotics)

49

Common symptoms for sickle cell traint

Hematuria, Inability to concentrate urine

50

Lab indications of sickle cell trait

sickling test positive, all else negative

51

Dubin-Johson = absence of

MRP2

52

Deconjugation of bile acids

Anaerobes, S aureus --> Less soluble --> Less able to form miscelles --> Lipid malabsorption

53

Lower border of parietal pleura

7th --> 10th --> 12th

54

Where should thoracentesis be performed

5-7 (midclavicular) --> 7-9 (midaxillary) --> 9-11 (paravertebral)

55

Unlike ACh, Succinylcholine is not

degraded by AChEsterases

56

Succinylcholine Phase 1 vs 2

1 is depolarized, 2 is non-depolarized

57

Relaxant for intubation --> Hyperkalemia

Succinylcholine

58

AE's of Succinylcholine

(1) Malignant hyperthermia; (2) Severe hyperkalemia; (3) Bradycardia

59

Who gets hyperkalemia with Succinylcholine

Burns, Myopathies, Crush injuries, Denervation

60

Atracurium releases

Histamine --> Fall in BP, Bronchoconstriction

61

Sensory from inner tympanic membrane, eustachian tube

CN IX

62

Noninfective envelope glycoprotein that forms spheres and tubules 22 nm in diameter

HBsAg

63

Milrinone

PDE 3 inhbitor --> Incr cAMP --> Ca conductance --> + Inotropy

64

Dipyridamole, Cilostazol

Decr platelet PDE --> Incr cAMP --> Decr platelet aggregation; Cilastazol also directly vasodilates

65

Ticlopidine, Clopidogrel MOA

Block ADP receptor --> Decr Gp Iib/IIIc receptor

66

Ingestion of undercooked shellfish

V cholera, Norwalk virus, Hep A

67

VPM receives input from

Superior Olivary Nucleus, Inferior Colliculus of Pons

68

Subacute Cerebellar Degeneration

Small cell, Female repo cancers --> Anti-Yo, -P/Q, -Hu --> Cross-react with cerebellar purkinje neurons

69

Post-viral Cerebellar Ataxia

Within 3 weeks of Varicella, Measles, EBV in children --> Self-resolving

70

Clinical associations with Adenocarcinoma

Clubbing, Hypertrophic osteoarthropathy

71

Location and clinical associations with Large cell carcinoma of lung

Peripheral; Gynecomastia, Galactorrhea

72

Carcinoid syndrome is associated with decreased

Niacin

73

Liver histology Reye's syndrome

Microvesicular steatosis w/out inflammation

74

Most adults in US with Anti-HAV IgG

Have never experience icteric illness

75

Icterus in HAV infection depends on

Age (children typically anicteric)

76

Petechiae, Purpura, Ecchymoses

Pupurua 5mm to 1cm