Mixed Block Notes 9 Flashcards Preview

Uworld > Mixed Block Notes 9 > Flashcards

Flashcards in Mixed Block Notes 9 Deck (75):
1

Ecthyma gangrenosum is strongly associated with

P aeruginosa

2

Virulence factors of Pseudomonas in Ecthyma gangrenosum

Exotoxin A (protein synthesis), Elastase, PLC, Pyocyanin (ROS)

3

Exposure to bats or bird droppins in Ohio or Mississippi area

Histo (resembles tuberculosis)

4

Chlorthalidone

Thiazide diuretic

5

Holocrine glands

Associated with sebaceous - entire cells secreted

6

Apocrine vs Eccrine

Apocrine secretes into hair follicles, Eccrine directly onto skin

7

Rapid y descent that becomes deeper and steeper during inspiration

Constrictive pericarditis

8

Timeline of T cell response to MTB

2-4 weeks after infection

9

Most dangerous complication of UC

Toxic Megacolon

10

Sacral micturation center

S2-S4 - parasympathetic fibers travel with pelvic nerves

11

Pontine Micturation Center

Pontine Reticular Formation

12

Medium chain acyl-CoA DH deficiency causes

Hypoglycemia, Hypoketonemia

13

Each round of FA beta oxidation produces

1 NADH, 1 FADH2, 1 AcetylCoA

14

During rapid beta oxidation, the TCA cycle is overwhelmed -->

Shunting acetyl-CoA toward production of ketone bodies

15

Acetyl-CoA Carboxylase

RLS - first step in FA synthesis

16

Anti-cholesterol meds that should be used with caution in patients with pre-existing GB disease

Bile acid resins, Fibrates

17

Parvovirus binds what antigen

Erythrocyte P antigen

18

EBV envelope glycoprotein gp350 binds what

C3d complement component (CR2 or CD21)

19

Hydrocephalus, Intracranial calcifications, Chorioretinitis

Congenital Toxo

20

What type of enzyme is telomerase

RNA-dependent DNA polymerase (RT)

21

Rifampin monotherapy

Exposure to H flu or N meningitidis

22

Tx of MAC

Macrloide + Rifampin + Ethambutol

23

Hurthle Cells

Hashimoto's

24

Beta-Galactosidase

Lactose --> Glucose + Galactose

25

Lac operon

Lack of glucose increases cAMP, Presence of Lactose binds repressor

26

FFA's and insulin resistance

Increase resistance, also decrease insulin secretion

27

Pyogenic granuloma

Polypoid form of capillary hemangioma - Resemble hypertrophic granulation tissue

28

Cystic hygroma

Endothelium-lined lymph spaces beneath epidermis - Differ from cavernous hemangiomas by absence of luminal vessels

29

Liver hemangiosarcomas are associated with

Arsenic (pesticides), Thorotrast (contrast), Polyvinyl chloride

30

Diet recommended for PDH deficiency

Ketogenic (Leucine, Lysine)

31

Glucogenic AA's

Methionine, Valine, Histidine (met sugary valiant hunk)

32

Glucogenic/Ketogenic AA's

Phenylalanine, Isoleucine, Threonine, Tryptophan

33

Ketogenic AA's

Leucine, Lysine

34

Mutation of Myelin protein gene

Charcot-Marie-Tooth (weakness of foot dorsiflexion)

35

Additional manifestations of Polycythemia Vera

Peptic ulceration, Pruritis, Gouty arthritis

36

Measure of fetal lung maturity

Incr ratio of phosphatidylcholine (lecithin) to sphingomyelin ratio

37

Primary abnormality in Paget's

Excessive osteoclastic bone resorption

38

Phenazopyridine

Urinary analgesic - provides symptomatic relief of dysuria, urinary frequency, urgency

39

Ascorbic acid accelerates what reactions

Hydroxylation, Amidation

40

Workup of all patients with gastrinoma should include

Serum calcium, PTH, and Pituitary hormones - MEN-1

41

Anti-MTB drug that requires acidic intracellular environment

Pyrazinamide

42

INH MOA

Synthesis of mycolic acid

43

Ethambutol MOA

Blocking Arabinosyl Transferase

44

Segmented viruses

Reovirus (rota, colti), Orthomyxo, Arena, Bunya

45

Excessive rise in left atrial systolic pressure (v wave) is characteristic for

Mitral Regurgitation

46

Differentiate bone-specific ALP

Easily denatured by heat (bone = boil)

47

Urinary hydroxyproline and deoxypyridinolin excretion

Osteoclast activity (most common measures), also TRAP

48

Antipsychotic most notorious for causing prolonged QT

Ziprasidone

49

Cardiac medication that can cause hypothyroidism

Amiodarone

50

Clozapine acts on what receptors

D4

51

Prevent intracelllular dehydration in sickle cell

Gardos channel blockers (ca-dep K channel)

52

Specificity of tPA

Can only bind plasminogen strongly in presence of fibrin = clot-specific

53

Most common elbow injury in children

Radial Head Subluxation = Tear of annular ligament

54

Blanching of vein into which NE is being infused + induration and pallor

NE extravasation --> a1 vasoconstriction --> Phentolamine

55

Respiratory muscarinic antagonists

Ipratropium, Tiotropium, Glycopyrrolate

56

Eye muscarinic antagonists

Atropine, Homatropine, Tropicamide

57

GI muscarinic antagonists

Hyoscyamine, Dicylomine

58

GU muscarinic antagonists

Oxybutynin, Solifenacine, Tolterodine

59

Flunisolide

Inhaled GC for prophylactic treatment of asthma (bronchial)

60

Calcific Tendonitis

Deposits of calcium hydroxyaptite crystals in periarticular soft tissues (esp tendons, rotator cuff)

61

Anti-EGFR Ab

Cetuximab

62

Muromonab

Anti-CD3 (acute rejection treatment for liver, kidney, heart)

63

Most common bugs causing sepsis in sickle cell

Pneumococcus, H flu

64

How does radiation kill cells

DNA ds break, ROS

65

Secretin stimulates pancreas to release

Bicarb rich, Cl poor fluid (Cl to produce NaCl)

66

High levels of what increase ESR

Fibrinogen stimulted by Acute Phase Reactants

67

Pure Red Cell Aplasia is associated with

Parvo B19, Thymoma, Lymphocytic Leukemias

68

Invasive Mole vs Choriocarcinoma

Hydropic villi and proliferated trophoblast vs Atypical cytotrophoblastic and syncytiotrophoblastic cells w/ foci of hemorrhage and necrosis

69

Pulsus alternans

LV dysfunction - Beat to beat variation in magnitude of pulse pressure in presence of regular rhythm

70

Dicrotic pulse

Two distinct peaks - Severe dystolic function

71

Pulsus parvus et tardus occurs in

Aortic stenosis

72

Hyperkinetic pulse

Rapid ejection of large stroke volume against decr afterload

73

Paget disease of nipple

DCIS spreads to nipple skin without having crossed basement membrane

74

Ductal dilation, Inspissated breast secretions, Chronic granulomatous inflammation in the periductal and interstitial areas

Mammary Duct Ectasia

75

Most common benign tumor of esophagus

Esophageal Leiomyoma