Module 7 Wk 3 Flashcards
(218 cards)
what is rigor mortis?
sustained muscle contraction after death caused by the absence of adequate ATP production
what is the motor unit?
myofibers innervated by a single axon
what kind of movement does small motor units?
fine movement
what kind of movement does large motor units produce?
generation of force
how would you examine muscle in vivo?
clinical pathology
- CK, ALT, AST count
- myoglobin
Electrophysiology
- electromyography - needle straight to muscle
- electroneougraphy - stimulate nerve to see what is going on eith the muscle
how would you examine muscle ex vivo?
Gross examination
- size
- texture
- colour
histological examination
what are the different responses muscles give in response to insults?
- hypertrophy
- atrophy
- degeneration and necrosis
- regeneration
- chronic myopathic change
why is it only a possibli;ity and not super commen for muscle to regenerate?
As muscles are post mitotic tissue so stable.
what happens to the size of the myofibers during atrophy of muscle?
reduced
What is the earliest stage of degeneration seen?
hypercontraction
what can be seen at hyaline degeneration?
homogenously eosinophillica fibres and loss of straitions
T/F you dont see mineralisation with acute necrossi of muscle
false see it with all necrosis
What is segmental degeneration and necrosis classified based upon?
- distribution and time line
what does regeneration of muscle depend on?
intact staellite cells and extent of damgae to basal lamina
If basal lamina is intact what happens?
- macrophages enter and remove debris
- satillite cells become myoblasts
- myoblasts fuse to form myotubes
- essentail structures reformed
- nuclei move to perfiferal position
= regeneration
what might you see with a vascular response in muscles?
Ischemia which is where blood flow is resricted or reduced
what are the potentail causes of ischemia?
- occlusion of large blood vessel
- external pressue on a muscle
- internal oressue on a muscle
- vasculitis - inflamation of the blood cells
what sensitive cells would you see during ischemia?
- myofibers
- satallite cells
- fibroblasts
What is the action of bacteria that causes inflammation in the muscle?
- penetrates wounds
- spread from adjacent site
- heamatogenous
what does nespora canium cause in muscle?
Causes cysts with bradyziotes in the tissue
What muscles does trichinella spiralis effect?
toungue, masticatory muscles, resp muscles and muscles of the eye
What types of injuries cause traumatic pathology of muscles?
- crushing injuries
- lacerations
- tearing or ruptures
What muscle is most likely to rupture?
diaphram
Name 4 congenital conditions that effect muscles
- x linked muscle dystrophy
- labrador centronuclear mypopathy
- hyperkalemic periodic paralysis
- euine polysaccharide storage myopathy