Flashcards in MODY and other genetic diabetes Deck (12)
What does MODY stand for>
maturity onset diabetes of the young
What is the inheritance for MODY?
How old are most patients when they present?
before age 25
What are the 2 phenotypes of MODY?
glucokinase and transcription factor- HNF-1alpha
What is the problem in a glucokinase mutation?
there is a defect in sensing glucose- it takes a higher level of glucose for the enzyme to recognise
What are the features of glucokinase MODY?
onset at birth; no treatment needed; stable hyperglycaemia; complications rare
What are the features of transcription factor mutations?
adolescence/young adult onset; progressive hyperglycaemia; complications frequent
What drugs are transcirption factor MODy sensitive to?
What are the 2 types of neonatal diabetes?
transient neonatal diabetes ; permanent neonatal diabetes
What is the time period that transient neonatal diabetes tends to resolve in?
What is the action of sulphonyureas?
close the Katp channel, depolarising the membrane and causing insulin secretion