Flashcards in Type 2 diabetes pathophysiology Deck (8)
Where is glycogen stored in the body?
liver and muscle
What are the steps leading to influx of caclium into the beta cell?
glucose enters cell, undergoes metabolism, producing ATP which closes the Katp channel and causes the PM to depolarise leading to caliucm influx
What are the core defects of type 2 diabetes
insulin resistance and beta cell dysfunction
What is insulin resistance?
when the receptor is not as responsive to the insulin molecule and so less glucose enters the cell, this results in a build up of glucose in the blood
What causes insulin resistance?
ectopic fat acccumulation and increased FFA circulation; increased inflammatory mediator----inhibition of insulin via serine kinases responsible for phosphorylation of IRS-1
What is beta cell dysfunction?
reduced ability of beta cells to secrete insulin in response to hyperglycaemia
How does insulin resistance result in decreased beta-cell function?