Morphogens

Question 1

What are 2 important characteristics of morphogens?

Answer 1

1. They induce different fates at different concentrations

2. They act directly at a distance

Question 2

What is restrictive diffusion?

Answer 2

When the signal binds to the extracellular matrix- helps create a more steep concentration gradient

Question 3

What are heparon sulphate proteoglycans?

Answer 3

Receptors found in the ECM that bind to many ligands- including morphogens
They can slow diffusion

Question 4

What is the transcriptional read out model?

Answer 4

The higher the concentration of morphogen, the higher the amount of activated transcription factor

Question 5

What is genetic cross-talk regulation?

Answer 5

When the activation of one gene produces a repressor which blocks the expression of another gene