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Flashcards in MS Deck (16):
1

who gets MS

young women from northern latitudes

2

What are some possible exposures that may lead to MS

Infection or Vitamin D deficiency

3

Genetics of MS

HLA DR2*1501

4

what is an exacerbation

neurological disturbance lasting at least 24 hrs in absence of fever or infection

5

Common presenting symptoms of MS

sensory disturbance, optic neuritis, motor disturbance, brainstem/cerebellar problems (vertigo, diplopia), bladder, congnitive, pain

6

Lhermitte's

brief electrical shock down spine on neck flexion

7

uhtoff's phenomenon

symptoms in setting of elevated body temp

8

visual findings in MS

APD, nystagmus, INO, optic pallor

9

motor deficits in MS

increased tone, brisk reflexes, clonus, babinski

10

Findings of MS pts

elevated IgG on LP (esp oligoclonal bands), periventricular plaques on MRI. Dawsons fingers in saggital MRI (brain atrophy due to axon loss)

11

Normal dz course. Other courses

Relapsing-remitting MS (no full recovery from exacerbations). Can progress to Secondary Progressive (gets worse b/w exacerbations). Primary progressive has no exacerbations

12

tx of acute exacerbation

steroids (methylprednisolone)

13

preventative tx. which to use during pregnancy?

IFN beta, glatiramer acetate (pregnancy), natalizumab

14

best way to tx gait problems

K channel blocker

15

Neuromyelitis optica (devic's dz)

optic neuritis, acute myelitis, longitudinally extensive spinal cord lesion (>3vertebrae), ab against aquaporin 4

16

when do you get acute disseminated encephalomyelitis

post ifneciton or post vaccination