MSK/Joints Flashcards Preview

Rotation 2: IM Outpatient > MSK/Joints > Flashcards

Flashcards in MSK/Joints Deck (46):
1

polymyalgia rheumatica (PMR)

who is it common in? what are the lab tests like? what is commonly associated with this disease? what do you use to treat this disease? how soon can people come off it?

>50, northern european ancestry 2:1 females

abrupt onset of intense morning stiffness of neck, shoulders and hip girdle but muscle strength is normal, fatigure and anorexia also common

elevated ESR >50 mm/hr and CRP

 

15% can get great cell arteritis/temporal arteritis

 

low dose steroids 10-20 mg only drug that works, looks to normalize the CRP and ESR

usually self limiting 65% taper of steroids 1 year, 85% in 2 years

2

what can people develop from Polymyalgia rheumatica (PMR) and what percent of people does this happen in?

giant cell arthritis/temporal areritis

15%

3

what should you do if the ESR and the CRP values for polymyalgia rheumatica (PMR) don't normalize with steroid use?

 

rethink the diagnosis

4

Systemic Lupus Erythematosis (SLE)

who is this common in? what happens? what are the four main body systems you worry about? what are the 11 presentations and how many do they need to have?

womens disease, 16-55, african american 15:1

debris from abnormal cell apoptosis promotes polyclonal B cels and autoantibodies, complexes deposit everywhere causing the symptoms

1. renal (nepthritis, nephrotic syndrome, tubulointerstitial disease)

2. neuro (seizures, psychosis)

3. hematologic (hemolytic anemia, leukopenia, lymphopenia ALL GO DOWN)

4. Immunological (vascular thrombosis) (antiophospholipid syndrome)

malar rash, arthritis without erosion just deformity, alopecia, raynauds, photosensitivity, positive ANA arthritis

must have 4/11 symptoms ANA is the only one that MUST be there

5

what are 8 lab tests seen in SLE?

1. CBC (anemia/cytopenias)

2. BUN/Cr (kidney involvment)

3. UA (proteinuria/ casts)

4. C3/C4 (decreased)

4. ESR ELEVATED, CRP NORMAL

5. positive ANA with all patterns EXCEPT centromere and SCL70

6. dsDNA that is more specific than ANA, speckled or nucleolar

6

SLE treatment

1. skin

2. renal

3. other

Skin/fatigue: hydroxychloroquine

renal: high dose corticosteroids and cyclophosphamadine (immunosuppressant)

 

other immuno:

azathioprine

mycophenalate

methotrexate

7

osteoarthritis

what is this? where is it most common? what are the two types? what would you expect to see on a xray?

joint disease with protective cartilage on the ends of your bones wears down over time and subchondral bone wears down over time >40 yrs olds THINK ELDERLY, slow developing joint pain

early onset and late onset OA, erosive

 hands, hips and knees most common

primary or secondary causes

 

joint enlargement, red swollen PIP, DIP, weakness and wasting of muscles around joint, deformities

xray: see narrowed asymetric joint space, with osteophyte formation, bony sclerosis

8

what is a osteophyte? what disease is this commonly seen in?

a bony outgrowth associated with the degeneration of cartilage at joints.

osteoarthritis

9

what are the characteristics associated with early osteoarthrits? (4 things)

1-2 years

morning stiffness lasting

they're ok, they say they just keep going

red, prominent PIP, DIP joints with normal radiographs

10

what are the characteristics associated with late osteoarthritis?

AM stiffness lasting

mechanical stiffness that gets worse with movement, more pain the more they do

claim not to have the same strength they used to (opening jars/doors etc)

little evidence of inflammation

ABNORMAL RADIOGRAPHS

get less symptomatic in non-weight bearing joints AKA many patients have extreme hand deformities but are asymptomatic (once they are deformed they don't hurt anymore)

11

what is the treatment options for osteoarthritis? (7 things)

joint conservation

exercise

weight loss

NSAIDs (caution with ulcers)

COX-2 inhibitor (safer for people with history of ulcers, but still need to watch for cardiac complications)

cartilage replacement (15-55)

total joint replacement

12

primary osteoarthritis is.....

idiopathic, arises spontaneously

13

secondary osteoarthritis can come from....

 

1. posttraumatic

2. congentiral deformation

3. endocrinopathy

4. neuropathic arthropathy

5.padgets disease

6. avascular necrosis

7. skeletal hyperostosis DISH

14

what is the most common joint disorder in the US?

osteoarthritis

15

Osteoarthritis of the hip

what is this? what will you see on the xray? what is the "definitive cure"? what other surgical interventions can you do in younger patients?

degredation of articular cartilage, thickening of the subcondral bone

 

progressive hip pain that often complain of groin pain, "crunching" noises aka crepitus

xray osteophyte formation, decreased joint space, sunchondryl sclerosis and cysts

conservative: same as always

definitive cure: total hip arthroplasty THA (replace joint)

surgical: arthroscopic debridement, femoral head resurfacing in younger patients

16

osteoarthritis of the knee

what is this? what are four presentations you see with this? what is a possible muscle presentation? what is the gold standard for diagnosis? what are the conservative vs surgical treatment options?

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degredation of the hyaline cartilage of the knee

pain is worse in AM, giving away or locking

joint hypertrophy, and tendernous at the joint line, possivle quadricept atrophy

 

gold standard: xray...see osteophyte formation, decreased joint space so bone on bone, sunchondral sclerosis

 

treatment: conservative normals plus cortisone injections and hyaluronic acid injections

surgical: knee arthroscopy, tibial/femoral osteotomy, total knee arthroplasty

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17

osteoarthris...explain what happens in this...

normal bone programming

"cartilage scenescence"--we outlive our chondrocytes around 25-30 years old, it frays and falls apart and the chondrocytes become hypertrophic and grow larger, however they produce enzymes MMP and aggrecanases that break down the cartilage and act like growth plate cells where THEY MAKE MORE collagen 1 and 9, BONE THAN BREAK IT DOWN...CARTILAGE CAN'T REGROW SO YOU JUST GET  INCREASED BONE GROWTH!!

"progressive loss of articular cartilage and reactive changes at the joint margins from bone rubbing on sunchondral bone rubbing on bone "behaves like a fracture" and stimulates chondrocyte hypertrophy and increased bone growth

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19

what are the common presentations of late osteoarthritis? (5)

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morning stiffness lasting

mechnical stiffness, gets worse with movement, more pain the more they do

not the same strength they used to (opening jars, turning handles)

abnormal radiographs! deformities obviously present, bone hypertrophies

get LESS symtomatic in non weight bearing joints, asymatic once they are deformed because they aren't able to move them

 

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20

what are the Early osteoarthritis presentations? (4)

1-2 years

morning stiffness lasting !!! "they're ok, they just keep going!"

red, prominent DIP  and PIP joint involvement

normal radiographs

21

what are the treatment options for someone with osteoporosis?

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Not much...its a natural bone programming

Its "supposed" to happen

-joint conservation

-exercise low impact

-weight loss to relieve load on joints

 

NSAIDS and COX-2, total joint replacement, autologous cartilage implantation (not many people qualify)

23

what joints are most commonly effected by osteoarthritis?

PIP, DIP, hips, knees

24

gout

what happens here? what do the crystal depositions look like?  what is effected commonly as a strange presentation in most cases? what are the two ways these crystals accumulate and what are the percentages? what hardened structure can be found within joints of chronic gout? what labs do you do? what is diagnostic? what is the difference between the treatment for acute and chronic treatment?

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most common form of inflammatory arthritis in m/w over 40

acute arthritis (usually at night) by sudden increase and deposition of uric acid crystals in the joint

great toe effected in 50% of cases, but can effect any joint in the body: ankles, knee, hands, wrists

cause: hyperuricemia, too much in circulation and in 90% of cases there isn't enough secreted from the kidneys instead of overproduction (10%)

joints contain tophi, hardened nodules (chronic)

 

Labs: uric acid levels, may have elevated WBC, uric acid crystals in joints are diagnostic, xray to access joint damage

 

Acute TX: NSAIDS, colchicine

Chronic: Xanthine oxidase inhibitor, allopurinol (blocks production) or probenecid (increases uric acid excretion)

 

 

 

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26

what do the crystals in gout look like?

needle like WITHOUT birefringence

27

what is the name when the big toe is effected by gout?

podogra

28

what is the most common cause of gout in people?

metabolic syndrome 75%

29

pseudogout

what is this caused by? what joint is the most commonly effected? what isn't present that is seen in regular gout? where do you see the deposits? what do the crystals look like under the microscope?

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acute inflammatory disease caused by calcium pyrophospate crystals

calcium pyrophosphate dihydrate disease

knees most commonly effected

*****no tophi present that differentiates from gout****

see calium deposits in the cartilage

aspiration see rod shapped crystals with blunt ends and befringement unlike gout

conservative and excision of chondrocalcinosis

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30

what are three interesting things that increase risk of gout?

alcohol, meat, seafoods

metabolic conditions

32

Reactive Arthritis (Reiter Syndrome)

what is this join infection caused by? what are the two most common routes a person can contract this? what are the 4 symtoms that are included as a part of this tetrad? what do you want to make sure you do? and what test will be negative? what do you treat with?

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joint inflammation that presents after PREVIOUS INFECTIONs commonly from sexually transmitted or gastroenteritis

chlamydia urethritis most common pathogen

Tetrad presentation:

1. urethritis (difficulty urinating,

2. conjunctivitis (eye inflammation)

3. olioarthritis (1-4 joints)

4. mucosal ulcers (oral, balantitis*peeling of skin on penis*, stomatitis *inflammation of the mouth)

5. keratoderma blennhoragicum rash/ulcers on bottom of feet

 

CULTURES WILL BE NEGATIVE. STRONG HLB-27 relationship 80%

Treatment: PHYSICAL THERAPY NSAIDS, can give abx but not very helpful in sxs

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33

infectious (septic) arthritis

how many joints does this involve? what joint is the most common? what is the most common agent? what are the four agents in children? what active people does this often effect and percent? what should you treat with until the cultures come back?

involves a single joint, most commonly the knee 90%

then hip, shoulder, anklet

Adults: S. aureus, streptococcus

children: Haemophilis influenzae, E. coli, pseudomonas, borrelia burgdoferi

sexually activite individuals have increased risk from Neisseria gonnoreah 50%

xray: may see gas in the joint space, arthrotomy and culture

treat until culture comes back: ceftrixaone, followed by 4 weeks of antibiotic after organism identified

 

34

in infectious (septic) arthritis....what must you always do if the hip is involved?

arthrotomy....test it and see what it is!!

36

what are te two bacteria seen in reactive arthritis in the sexually transmitted pathway?

chlamydia urethritis

ureaplasma

9:1 Men

37

what are the 4 bacteria you should worry about in reactive arthritis that you should worry about in the gastroenteritis pathway?

Yersina

Salmonella

Shigella

Campylobacter

38

herniated nucleus pulposus

what happens in a herniation? where does this most commonly occur in the vertebrae and in the spinal cord? what will the 3 main symptoms be and what are 3 things a patient will get pain with that are normal things? what do you do for treatment?

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this is when the nucleus pulposus, the soft gelatinous center is herniated posteriorally since this is where the annulus fibrosis is the weakest!!!

usually  occurs in lumbar spine since takes the most load

see motor and sensory manifestation

-tingling, numbness, or burning pain (seen in sagital and axial MRI images)

-pain with coughing, sneezing, and laughing

 

RICE, NSAIDs, surgery

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40

spinal stenosis

what is this caused by? what two conditions for the risk of stenosis increase with? what unique thing makes this better, and what makes this worse? what can you see the in the lumbar region? what will you see on the MRI? what can you do for treatments for this?

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compression  of nerves of spinal cord caused by narrowing of the spinal cord and foramen

commonly seen in spondylosis and degenerative arthritis

pain increases with walking or axial loading (leaning back), and decreases with leaning forward, flexion!

back and leg pain, soft tissue and thecal narrowing, can see loss of lumbar lordosis

 

TX: acetaminophen, weight reduction, pelvic tilt, abdominal exercises....last choice decompressive surgery

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41

osteoporosis

what is this? who is it most common in? what is the nickname for this disease? what imaging type do you want to preform? what 3 presentations might you find on physical exam?

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abnormal bone remodeling, decrease in the total volume of bone making it less dense, since less strong it leads to increased fractures!

imbalance between bone formation and reabsorption

most common in menopausal women

"silent disease"

 

presentation: height loss, kyphosis, severe cervical lordosis dowagers hump

 

Dexxa scan of spine and hip

 

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42

what test should you do for herniated disk pulposa?

straight leg test

pain at 

45

explain what happens in rheumatoid arthritis?

affects the lining of multiple joints synovitis, causing a painful swelling that can eventually result in bone erosion and joint deformity, autoimmune (not wear and tear like osteoarthritis)

 

hyperplastic synovial tissue called pannus erodes the cartilage, subchondral bone, tendons, and ligs "like a line of soldier marching to battle and destroying everything in their pathway. joint erosion

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46

what is an abnormal DEXA scan result that can indicate osteoporosis?

-2.5 and below

47

what are the treatment options for osteoporosis? (3)

 

1. bisphosphonates: inhibits osteoclasts (jaw necrosis)

2. HRT, estrogen, or progesterone (stroke, breast cancer)

3. selective estrogen receptor modulator (serms)

48

rheumatoid arthritis

what are the four criteria for diagnosis?

1. morning stiffness >1 hour, usually don't feel better till 10-11 am

2. arthritis of >3 joints and soft tissue, immune system is activated!

3. symmetrical!!

4. >6 weeks!

49

why is it important to always look at the feet of a rheumatoid arthritis pt? if suspicious they have it what is important to do?

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see it on the feet before the hands so really important to get xrays of both the hands and feet!!

ALWAYS DO BOTH!!

if suspicious on physical exam, must feel joints because you will feel the difference between individual joints!

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51

what two tests do you want to run for someone with rheumatoid arthritis? which is more specific?

RF: 65-70% positive

A-CCP: POSITIVE 70, more specific

52

what is the a specific indicator for Rheumatoid arthritis that isn't seen in ANY OTHER DISEASE!!!!!!

cyclic citrullinated protein

53

when is the most critical point to catch Rheumatoid arthritis? what is the difference in the timeframe for progression? when are you likely to see radiologic changes?

ASAP

will see radiographic changes

rapid during first year compared to second and thurs

"at first its a fire and an entire war so need to get treatment asap, the second wave is just the reserve and the damage and action has already taken place"

55

what three joints does RA commonly effect?

MCP, PIP, wrist

also feet fyi

56

explain the medication treatment rational for rheumatoid arthritis!!

3 conditions

1. methotrexate

2. in partial or non responders frm 4-8 weeks, get them on biologic DMARD ETANERCEPT combined with Methotrexate!!

3. if erosions at time of xray, then go straight to Etanercept or biologic dmards!