Flashcards in muscle and the neuromuscular junction Deck (13):
what would this indicate>
lower motor neurone problem
most common disorder of neuromuscular junction?
autoimmune antibodies to acetyl choline receptors
clinical features of myasthenia gravis?
fluctuating weakness- worse through day
extraocular weakness, facial and bulbar weakness
limb weakness- typically proximal
how do you treat myasthenia gravis?
pyridostimine ( acetly chlonesterase inhibitor)
what are fasciculations?
visible fast fine spontaneous twitch
can occur in healthy muscle die to anxiety, caffeine, or stress or fatigue
occurs in denervated msucle which become hyperexcitable
what is myotonia?
failure of muscle relaxation after use
main symptoms of muscle disease?
name some inflammatory disease that effect muscle?
polymyositis and dermatomyositis
name some inherited conditions which effect muscle?
name a degenerative disease which affects muscle?
inclusion body myositis
what happens in rhabdomyolysis?
damage to muscle causes leakage of large quantities of toxic intracellular contents into plasma