muscle and the neuromuscular junction Flashcards Preview

Neurology year 3 > muscle and the neuromuscular junction > Flashcards

Flashcards in muscle and the neuromuscular junction Deck (13):
1

what would this indicate>

weakness
low tone
fasciculations?

lower motor neurone problem

2

most common disorder of neuromuscular junction?

myasthenia gravis

3

autoimmune antibodies to acetyl choline receptors

myasthenia gravis

4

clinical features of myasthenia gravis?

fluctuating weakness- worse through day
extraocular weakness, facial and bulbar weakness

limb weakness- typically proximal

5

how do you treat myasthenia gravis?

pyridostimine ( acetly chlonesterase inhibitor)

thymectomy
immunomodulating
steroids

6

what are fasciculations?

visible fast fine spontaneous twitch

can occur in healthy muscle die to anxiety, caffeine, or stress or fatigue

occurs in denervated msucle which become hyperexcitable

7

what is myotonia?

failure of muscle relaxation after use

8

main symptoms of muscle disease?

myalgia
muscle weakness
wasting
hyporelfexia

9

name some inflammatory disease that effect muscle?

polymyositis and dermatomyositis

10

name some inherited conditions which effect muscle?

muscle dystrophies

myotonic dystrophies

11

name a degenerative disease which affects muscle?

inclusion body myositis

12

what happens in rhabdomyolysis?

damage to muscle causes leakage of large quantities of toxic intracellular contents into plasma

13

myalgia
weakness
myoglobinuria

rhabdomyolysis