Mycobacterium Tuberculosis Flashcards Preview

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Flashcards in Mycobacterium Tuberculosis Deck (64):
0

Also known as Koch bacilli, AFB or Tubercle bacilli, Captain of all men of death.

Mycobacterium tuberculosis

1

AFB and gram + bacilli aerobic, NM, NS, NE; requires enriched media and 5-10% of CO2.

Mycobacterium tuberculosis

2

Slow grower with a generation time of 20 hours; multiply by fermentation; contains much granules; requires whole egg for growth; produces cauliflower like growth on culture medium, luxuriant growth (eugonic); causes tuberculosis in man; long, slender, granular curved or rounded end.

Mycobacterium tuberculosis

3

Medium used in mycobacterium tuberculosis.

Lowenstein, petroffs, Dorset's, corpers

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Pathogenecity of mycobacterium tuberculosis

No toxins produced

5

Spinal disease of TB

Pott's disease

6

Skin disease of TB

Lupus Vulgaris

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Cervical lymph nodes disease of TB

Scrotula

8

Also know as leprae bacilli, hansens bacilli

M.Leprae

9

exhibits cigar packet arrangement
Non culturable on artificial medium but can be maintained in the footpads of armadillo
Causes leprosy

M.leprae

10

Anesthetic type; non-progressive and benign with few organism on skin lesions; + leprominb test

Paucibacillary (Tuberculoid Leprosy)

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Nodular type; course is progressive and malign with numerous organisms on skin lesions: - lepromin test

Multi bacillary (Lepromatous leprosy)

12

Differentiating point of M.gordonae from M.scrofulaceum

Tween 80
+ M.gordonae
- M.scrofulaceum

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Differentiates M.fortuitum-Chelonei + from M.phlei -

Arylsulfatase test

14

M.fortuitum +

Iron Uptake test

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Differentiates M.flavescens + from M.szulgai -

NaCl tolerance test

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Causes TB in cows; source of Bacille Calmette Guerin

M.bovis

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Pigment colonies presence of light

Photochromogens

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Photochromogens

M.szulgai
M.kansasii/M.simiae/M.marinum

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Pigments colonies in the presence of darkness/light

Scotochromogens

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Schotochromogens

M.scrofulaceum
M.szulgai
M.gordonae
M.xenopi

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Non-Photochromogens and Rapid Growers; - to niacin and nitrate, + tween 80 and heat stable catalase

M.malmoense

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Non-photochromogens and Rapid Growers; requires Hemin for growth.

M.haemophilum

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Non-photochromogens and Rapid Growers; battery bacillus; all tests are - except for the heat stable catalase and pyrazinamidase test

M.avium-intracellulare

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Non-photochromogens and Rapid Growers; may be isolated from gastric lavage

M.gastri

25

The rapid growers;
+ pink to red color

Arysulfatease test

26

Strongly + to Arysulfatease test

M.fortuitum

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+ to Arysulfatease test

M.chelonei

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Negative or weakly + Arysulfatease test

M.phlei and M.smegmatis

29

The slow growers. Positive

Niacin test

30

Gm+ bacilli, NM, NE, alpha hemolytic on BAP. Catalase, INDOLE, oxidase and nitrate negative; ferments glucose and lactose. May cause erysipeloid. H2s positive, produce h2s in the butt of TSI media; is better know as veterinary pathogen than as a human pathogen.

Erysipelothrix rhusiopathiae

31

Colonies of Erysipelothrix rhusiopathiae were described as

Lampbrush or test tube brush.

32

When cultured on blood agar or some other nutrient medium Erysipelothrix rhusiopathiae forms.

Notably large colonies.

33

Treatment of Erysipelothrix rhusiopathiae usually consist of

Penicillin G, ampicillin or cephalonthin

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Most clinical strains of Erysipelothrix rhusiopathiae have been found to be resistant

Super-antibiotic vancomycin

35

Small grm + coccobacilli, NAF, shows tumbling motility; Can grow on 25-35,40 and 42C; catalase and vp test +; indole, oxidase and urease test negative; ferments glucose, maltose; bile Esculin hydrolysis +

Listeria Monocytogenes

36

Listeria monocytogenes on BAP

Produce a narrow band band of beta hemolysis

37

On agar surface the Erysipelothrix rhusiopathiae

Produce umbrella like growth "Inverted Chrismtas tree pattern

38

Erysipelothrix rhusiopathiae can cause

Listeriosis, Meningitis, Meningoencephalitis and perinatal septicemia.

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Two species of human pathogenic significance in listeria monocytogenes

Listeria monocytogenes and listeria Ivanovo

40

Susceptibility test for Listeria Monocytogenes. Suspension into rabbit eye or guinea pig. + result purulent conjunctivitis develops after 24 hours.

Anton's test

41

Commonly known as probiotic or good bacteria. Normal flora of the mouth, GIT and vaginal canal. Rare cause of bacteremia and pneumonia; produce large qnty of lactic acid. Gm+, catalase -, pleomorphic, NM, H2S -, does not hydrolyze Esculin

Lactobacillus acidophilus

42

If one fermenter is produced

Homofermenter

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Numerous fermentation and there are products other than lactic acid

Heterofermenter

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Common name of Lactobacillus acidophilus

Doderlein bacillus

45

Products like yoghurt

L.bulgaricus

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For yakult milk

Lactobacillus-shirota strain

47

Swiss cheese

L.delbruecki subsp. bulgaricus

48

Can also be found in the intestine

L.cassei

49

Facultative anaerobe and multiplied by transverse fission; all are M producing axial fibrils, a long flagellum like intracellular organelle that are responsible for its motility. Unicellular organisms with flexus structure. Dark field microscopy

Spirochetes

50

Causative agent of syphillis

T.pallidum

51

Disease of blood vessel and peri vascular areas

Syphillis

52

Commonly observed during the early stages when treated with penicillin

Jarisch-Herxheimer Reaction

53

Closely resembles tawa

Bejel

54

Disease of bones and skin, non verenal, transmitted thru aids of of flies; causative agent of yaws

T.pertenue

55

Infection if the feet which cause a crippling form of disease

Crab yaws

56

Affects only the skin and becomes de pigmented; causative agent of carate or punta which is characterized by hyperpigmented lesion.

T.carateum

57

Thin, flexible organisms with tightly coiled spirals and one or both ends mag be bent to form a hook. Strict aerobic, oxidase and catalase +, peroxidase +; causative agent of Weil's disease

Leptospira

58

Other names of leptosira

Swineherd's disease, Fort Bragg Fever, Pretibial Fever, canicola fever and autumnal fever

59

2 recognized fever of leptosira

Leptosira interrogans and leptosira biflexa

60

Disease produced is relapsing fever, tick fever, borreliosis or famine fever. Loosely coiled, irregular in shape, highly flexible spiral organisms, motile, microaerophilic. Can be visualized by staining with aniline dyes.

Borria

61

Louseborbe or epidemic relapsing fever which is transmitted to man by the human body louse.

Borrelia recurrentis

62

Tick borne or endemic relapsing fever which is transmitted to man by ticks:Ornithodoros species.

Borrelia turicatae and Borrelia parkeri

63

Causative agent of avian spircohetosis

Borrelia anserina