Myeloma

Question 0

What causes bone disease in myeloma?

Answer 0

Local activation of osteoclasts by plasma cells

Question 1

What are the possible patterns of secretion of plasma cells in myeloma?

Answer 1

• IgG with or without free light chains
• IgA with or without free light chains
• Free light chains only
• Other patterns of paraprotein

Question 2

What are the radiological manifestations of myeloma?

Answer 2

Generalised osteopaenia

‘Punched-out’ lytic lesions at site of plasma cell deposits

Question 3

What is a plasmacytoma and when is it seen?

Answer 3

Localized proliferations of plasma cells outside of bone

Seen in multiple myeloma

Question 4

What protein is found on urine electrophoresis in multiple myeloma?

Answer 4

Bence Jones Protein