Necrosis Flashcards

1
Q

what is the definition of necrosis?

A

a condition of cell death thru injury of diseases, especially ina localized area of the body

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2
Q

whatv poart of the cell goes under digestion?

A

cytoplasm

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3
Q

What does the lysosome of the necrotic cell release?

A

lysosomal enzymes

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4
Q

what is coagulative necrosis?

A

implies the preservation of basic outline of the coagulated cell for period of at some days

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5
Q

what 3 things is necrosis characterized by?

A

a. denature of cyto plasmic proteins
b. break down of cell organelles
c. cell swelling

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6
Q

what is white infartion?

A

single blood supply

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7
Q

what is red infarction?

A

dual blood supply

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8
Q

what is liquefactive necrosis?

A

complete digestion of cells resulting in transformation of tissue into a liquid viscous mass

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9
Q

what is an example of liquefactive necrosis?

A

ischemic stroke of the brain

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10
Q

wha t is casseous necrosis?

A

amorphous granular debris seemingly composeed of fragmanted coagulated cells

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11
Q

what is amorphous granular debris?

A

enclosed within a distictive site inflammatory border known as granulomatous reaction

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12
Q

what does granuloma mean?

A

collection of immune cells that are trying to get rid of a foreign substance

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13
Q

what are examples of casseous necrosis?

A

TB and leprosy

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14
Q

what is gummatous necrosis?

A

develops only in syphilis

death of tissue is caused by treponema pallidum

usually acquired by sexual transmission

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15
Q

what is primary syphilus?

A

single chancre

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16
Q

what is secondary syphilus?

A

involves skin usually hands and feet

17
Q

what is tertiary syphilus?

A

involves the aorta 80-85% of the time years later

and involves the CNS 5-10% of the time

18
Q

What part of the spine does tertiary effect?

A

the posterior columns

19
Q

what name does it receive when effecting the posterior columns?

A

tabes dorsalis

20
Q

what is the name when the grey matter is atrophied?

A

general paesis

aka general paresis of insane

21
Q

what are characteristics of Zenkers necrosis?

A

glassy waxy necrosis of the skeletal muscle

22
Q

what is zenker’s necrosis (the disease) called?

A

typhiod fever

23
Q

how do you contract zenkers necrosis?

A

salmonella bacteria

can also be caused by a snake bite

24
Q

what is fat necrosis?

A

necrosis of the adipose tissue

characterized by small quantities of soap bubbles

25
where does fibriniod necrosis occur?
in the walls of blood vessels when edothelial cells and smotth muscle cells are injured/dying
26
what is an example of fibrinoid necrosis?
Aschoff's nodes; seen in rhuematic fever
27
what is gangrene necrosis characterized by?
anaerobic bacterial metabolism
28
what causes dry gangrene ischemia?
lack of oxygen supplied to an organ or tissue
29
dry gangrene in the distal parts of the body is known as?
systemic sclerosis
30
what is atherosclerosis?
Buerger's disease affects nerves and veins not arteries caused by smoking
31
what is dry gangrene diabetes mellitus?
obliteration of the distal small vessels
32
what is wet gangrene?
phagocytic cells break down the necrotoc debris and produce some liquefaction
33
what causes wet gangrene?
anaerobic bacteria clostridium perfringes and bacillus fusiform
34
Wet gangrene in the distal parts of the fingers in known as?
polyarteritis nodosa
35
what causes intestinal gangrene?
anaerobic bacteria
36
what is gas gangrene?
bacterial infection that produces gas within tissue common inthe military
37
what causes gas gangrene?
clostridium perfrimges anaerobic streptoccocci