Neoplasia

Question 0

C-myc asc/prod

Answer 0

Burkitt’s lymphoma
Transcription factor
Oncogene

Burkitt’s lymphoma associated with malarial susceptibility to EBV

Question 1

Abl association/gene product

Answer 1

CML/tyrosine kinase

Oncogene

Question 2

Bcl-2

Answer 2

Follicular and undifferentiated lymphomas
Inhibits apoptosis
Oncogene

Question 3

Ras

Answer 3

Colon carcinoma

Oncogene

Question 4

HER-2

Answer 4

Breast, ovarian, gastric carcinoma

Oncogene

Question 5

L-myc

Answer 5

Lung tumor

Oncogene

Question 6

Rb

Answer 6

Retinoblastoma
Osteosarcoma

Blocks G1 -> S phase

Tumor suppressor gene TSG

Question 7

P53

Answer 7

Most cancers
Blocks G1 to S
TSG

Question 8

BRCA 1&2

Answer 8

Breast and ovarian

TSG

Question 9

DPC4

Answer 9

Pancreatic cancer

TSG

Question 10

DCC

Answer 10

Colon cancer

TSG

Question 11

PSA

Answer 11

Tumor marker
Prostate specific antigen
Used to confirm diagnosis, never primary

Question 12

CEA

Answer 12

Tumor marker
CarcinoEmbryonicAntigen

Colorectal, pancreatic, gastric, breast, medullary thyroid

Question 13

A-fetoprotein

Answer 13

T.m.
Made by fetus
Hepatocellular carcinoma

Question 14

Beta hCG

Answer 14

T.m.
Hydatidiform moles
Choriocarcinoma

Question 15

CA-125

Answer 15

T.m.

Ovarian cancer

Question 16

Alkaline phosphatase

Answer 16

Metastasis to bone, liver

T.m.