Liver Function Test Flashcards
Where is Alkaline Phosphatase from?
liver, bone, placenta, kidney, intestine
ALT/AST (aminotransferase) injury location differentiation
ALT: hepatocellular (also in kidney in muscle)
AST: heart, skeletal, RBCs
GGT (Gamma-glutamyltransferase)
location and function
liver, pancrase, renal tubules, intestines
NOT in bone.
Determines if alk phos is from bone or liver
Indicator for alcoholic liver disease
AST/ALT ratio is 2:1 or greater
AlkPhos and GGT both elevated
Hallmark of Primary Biliary Cirrhosis
Antimitochondrial antibodies (AMA)
Markers for Primary Biliary Cirrhosis
Increase Alk Phos, GGT
Nonalcoholic Fatty Liver Disease
ALT>AST
How is iron regulated in the body?
Enterocytes uptake iron, and excrete it into the body only when it’s needed.
Primary Hemochromatosis is missing this regulation, which results in overload, and hemosiderosis.
Primary Hemochromatosis due to
Mutation in HFE gene, most commonly C282Y
Classic triad of Hemochromatosis
Cirrhosis, Secondary diabetes mellitus (bronze diabetes), bronze skin
Presentation of hemochromatosis
Increased ferritin
Decreased TIBC
Increased serum iron
Increased percent saturation
Jaundice bilirubin levels
2-3mg/dl
originally around 1mg/dl
Nonalcoholic Fatty Liver Disease
ALT>AST
How is iron regulated in the body?
Enterocytes uptake iron, and excrete it into the body only when it’s needed.
Primary Hemochromatosis is missing this regulation, which results in overload, and hemosiderosis.
Primary Hemochromatosis due to
Mutation in HFE gene, most commonly C282Y
