Anemia 4

Question 0

More than ____ lobes indicates hypersegmented neutrophils… indicative of…

Answer 0

more than 5 lobes indicative of macrocytic anemia

Question 1

Macrocytic Anemia (aka megaloblastic anemia) due to deficiency in…

Answer 1

Folate (tetrahydrofolate-THF) or vitamin B12

Question 2

How long does it take for macrocytic anemia to occur if folate is removed from diet?

Answer 2

A couple months

Question 3

Why is there increased serum homocystine in macrocytic anemia?

Answer 3

Methyl group is attached to THF which then passes it on to Vit B12, which then passes it on to HOMOCYSTINE which then becomes methionine

No precursors, means extra homocystine in system

Question 4

How long does it take to develop Vt B12 deficiency?

Answer 4

Years

b/c large Hepatic stores

Question 5

What is pernicious Anemia?

Answer 5

Autoimmune destruction of parietal cells leading to Vt B12 deficiency b/c Intrinsic factors aren’t being produced

Question 6

Methylmalonic Acid increases in____

Results In…

Answer 6

B12 deficiency. Combined with B12 to form Succinyl CoA

methylmalonic acid builds up in spinal cord leading to Subacute Combined Degeneration of the Spinal Cord