Nephrotic and Nephritic Syndrome Flashcards Preview

Hugh's MD3 Paediatrics > Nephrotic and Nephritic Syndrome > Flashcards

Flashcards in Nephrotic and Nephritic Syndrome Deck (5):
1

What is the pathophysiology of nephrotic syndrome?

- Derangement of glomerular capillary walls causing increase protein permeability
- Can be in the endothelium, glomerular, or visceral epithelial cells and the defect can be structural or physiochemical

2

What are the features of nephrotic syndrome?

- Massive proteinuria (more than 3.5g per day)
- Hypoalbuminaemia
- Widespread oedema
- Hyperlipidaemia and lipiduria
- Prothrombotic state

3

What are the causes of nephrotic syndrome in kids?

- Primary Renal disease
○ Minimal change disease
○ Focal segmental glomerulosclerosis
○ Membranoproliferative
○ Membraneous glomerulopathy
○ Other proliferative glomerulonephritis
- Systemic
○ SLE
○ Drugs - NSAIDs
○ Infections
○ Malignant - carcinoma, lymphoma
○ DM
○ Amyloides
○ Other

4

What is the pathophysiology of nephritic syndrome?

- Inflammation and proliferation of glomerular cells

5

What are the features of nephritic syndrome?

- Haematuria
- Red cell casts in urine
- Azotemia
- Oligouria
- Mild to moderate hypertension
- Can also get proteinuria and oedema but not as severe as in nephrotic