Flashcards in Nephrotic and Nephritic Syndrome Deck (5):
What is the pathophysiology of nephrotic syndrome?
- Derangement of glomerular capillary walls causing increase protein permeability
- Can be in the endothelium, glomerular, or visceral epithelial cells and the defect can be structural or physiochemical
What are the features of nephrotic syndrome?
- Massive proteinuria (more than 3.5g per day)
- Widespread oedema
- Hyperlipidaemia and lipiduria
- Prothrombotic state
What are the causes of nephrotic syndrome in kids?
- Primary Renal disease
○ Minimal change disease
○ Focal segmental glomerulosclerosis
○ Membraneous glomerulopathy
○ Other proliferative glomerulonephritis
○ Drugs - NSAIDs
○ Malignant - carcinoma, lymphoma
What is the pathophysiology of nephritic syndrome?
- Inflammation and proliferation of glomerular cells