Neural Communication Flashcards

(48 cards)

1
Q

How do neurons communicate with each other

A

Combination of electrical activity (within neuron) and chemical activity (between neurons).

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2
Q

Action potential

A

Change in voltage that moves along the axon

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3
Q

Potential

A

Change in voltage

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4
Q

Depolarised

A

Less negative

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5
Q

What voltage triggers action potential

A

-65mV

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6
Q

Resting action potential

A

-70mV

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7
Q

Peak action potential voltage

A

+45mV

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8
Q

Hyperpolarised

A

More negative

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9
Q

Stages of action potential

A

Action potential triggered to -65mV, membrane potential reaches peak value of +45mV, potential depolarises to be less negative than resting potential.

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10
Q

Why does action potential propagate along an axon

A

Action potential triggers action potentials in adjacent areas.

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11
Q

What happens if depolarisation threshold isn’t met

A

Voltage propagates along the axon but is subject to ‘decay’

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12
Q

Salatory conduction

A

Conduction along a myelinated axon

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13
Q

Why does cable conduction occur in salatory conduction

A

Action potential cannot regenerate due to myelination

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14
Q

Where is action potential regenerated in salatory conduction

A

Nodes of ranvier

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15
Q

Refractory period

A

Time period following generation of action potential when no new action potentials can be started, or are harder to start

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16
Q

Absolute refractory period

A

New action potential cannot be initiated

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17
Q

Relative refractory period

A

New action potential is more difficult to initiate

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18
Q

Action potential is described as

A

An all or nothing event

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19
Q

Synapse

A

Junction between terminal button and a neurones cell membrane

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20
Q

What causes release of neurotransmitter into synaptic cleft

A

Action potential arriving at terminal buttons

21
Q

Where does the neurotransmitter bind to on the synapse

A

Receptor sites on postsynaptic neurone

22
Q

What happens after the neurotransmitter binds to receptor sites

A

May increase or sometimes reduce the likelihood of the cell depolarising

23
Q

Where does axodendritic synapses occur

A

The surface of a dendrite or dendritic spine

24
Q

Where do axosomatic synapses occur

A

On a cell membrane

25
Where do axoaxonic synapses occur
Between two terminal buttons
26
Postsynaptic potential
Alterations in membrane potential of a postsynaptic neuron produced by liberation of neurotransmitter at the synapse
27
Binding site
Location on a receptor protein to which a ligand binds
28
Ligand
A chemical that binds with the binding site of a receptor
29
Dendritic spine
Small bud on surface of a dendrite with which a terminal button of another neuron forms a synapse
30
Presynaptic membrane
Membrane of a terminal button the lies adjacent to postsynaptic membrane and through which the neurotransmitter is released
31
Postsynaptic membrane
The cell membrane opposite the terminal button in a synapse; the membrane of the cell that receives the message
32
Synaptic cleft
Space between the presynaptic membrane and the postsynaptic membrane
33
Synaptic vesicle
A small, hollow, bead like structure found in terminal buttons, contains molecules of a transmitter
34
Three steps of neurotransmitter release
- some synaptic vesicles are ‘docked’ at presynaptic membrane. - arrival of action potential causes calcium channels to open in terminal button. - Ca+ ions enter the terminal button causing vesicles to release.
35
Three processes of the fate of vesicles
- kiss and stay - kiss and leave - merge and recycle
36
Ionotropic receptor
Contains binding site for a neurotransmitter and an ion channel that opens when molecule of neurotransmitter attaches to binding site.
37
Metabotropic receptor
Contains binding site for a neurotransmitter; activates an enzyme that begins series of events that opens ion channel elsewhere in membrane of the cell when a molecule of the neurotransmitter attaches to binding site.
38
G protein
Protein couples to a metabotropic receptor; conveys messages to other molecules when a ligand binds with and activates the receptor.
39
Second messenger
Chemical produced when a G protein activates an enzyme; carries a signal that results in the opening of the ion channel or causes other events to occur in the cell.
40
Excitatory potential (EPSEP)
Excitatory depolarisation of the postsynaptic membrane of a synapse caused by liberation of a neurotransmitter by the terminal button.
41
Inhibitory postsynaptic potential (IPSP)
Inhibitory hyperpolarisatoon of the postsynaptic membrane of a synapse caused by the liberation of a neurotransmitter by the terminal button
42
Postsynaptic potential effect determined by
Postsynaptic receptor, NOT the neurotransmitter
43
Reuptake
Neurotransmitter transporter mechanisms rapidly remove the transmitter from the synaptic cleft and return it to terminal button
44
Enzymatic deactivation
Enzymes that destroy the neurotransmitter are released into the synaptic cleft
45
Neural integration
Process where inhibitory and excitatory potentials summate and control the rate of firing of a neuron
46
Autoreceptor
Receptor molecule located on a neuron that responds to the neurotransmitter released by that neuron
47
Presynaptic inhibition
Action if a presynaptic terminal button in an axoaxonic synapse; reduces amount of neurotransmitter released by the postsynaptic terminal button.
48
Presynaptic facilitation
Action of a presynaptic terminal button in an axoaxonic synapse; increases the amount of neurotransmitter released by the postsynaptic terminal button