NEURO - alzheimer medications

Question 1

exemplar drug for cholinesterase inhibitors

Answer 1

DONEPEZIL

Question 2

routes for DONEPEZIL

Answer 2

PO

Question 3

uses of DONEPEZIL

Answer 3

improve cognitive function in MILD to MODERATE alzheimers & delay progression

Question 4

pharmacologic action of DONEPEZIL

Answer 4

prevents acetylcholinesterase from breaking down acetylcholine –> more acetylcholine for brain function –> slows progression, more function, NOT A FULL CURE

Question 5

adverse reactions of DONEPEZIL

Answer 5

• nausea
• GI distress
• insomnia
• headache
• dizziness
• bradycardia

Question 6

nursing interventions of DONEPEZIL

Answer 6

• observe for CV issues
• observe s/s of GI bleeding
• assist with ambulation

Question 7

client education of DONEPEZIL

Answer 7

should NOT be take with food AT bedtime
- bc of insomnia

Question 8

interactions with DONEPEZIL

Answer 8

• antihistamines decrease effect
• if used with NSAIDs –> increased risk of GI bleeding

Question 9

exemplar drug for NMDA receptor antagonists

Answer 9

MEMANTINE

Question 10

route for MEMANTINE

Answer 10

PO

Question 11

uses for MEMANTINE

Answer 11

slows cognitive decline in MODERATE to SEVERE alzheimer’s

Question 12

pharmacologic action of MEMANTINE

Answer 12

blocks glutamate from stimulating NMDA receptors –> reduces intracellular calcium –> restores transmission & prevents damage to neuron from calcium influx
- prevents calcium from breaking down more cells
- slows progression
- improves symptoms

Question 13

adverse reactions of MEMANTINE

Answer 13

• dizziness
• headache
• confusion
• possible constipation

Question 14

nursing interventions for MEMANTINE

Answer 14

monitor for CNS issues & constipation

Question 15

client education of MEMANTINE

Answer 15

report side effects

Question 16

interactions with MEMANTINE

Answer 16

OTC antacids can increase levels of MEMANTINE