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Flashcards in Neurodegenerative Disease Deck (97)
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0

What does neurodegenerative disease affect

nerve cells and glial cells

1

What is neurodegenerative disease a loss of

Cells in the brain and spinal cord

2

List 4 diseases involving degeneration of CNS neurons

1. Dementia
2. Extrapyramidal disorders
3. Ataxic disorders
4. Motoneuron disorders

3

Give examples of dimentia

- Alzheimer's disease
- picks disease

4

What is the most common version of dementia

Alzheimer's disease

5

Give examples of extrapyramidal disorders

- Parkinson's disease
- Wilson's disease
- Huntington's chorea
- dystonia musculorum deformans
- hallervorden-Spatz syndrome

6

Give examples of ataxic disorders

- friedreich's ataxia
- cerebello-olivery atrophy
- cerebellar atrophy

7

Give and example of motoneuron disorders

Motoneuron disease

8

In which part of the brain does dementia cause degeneration of neurones

Cerebral cortex

9

Which is the most common version of extrapyramidal disorders

Parkinson's disease

10

Which sort of movements is involved in diseases from extrapyramidal disorders

Involuntary

11

Which sort of spinal disorder is linked with ataxic disorders

Cerebello spinal disorder

12

How many people does Parkinson's affect

1 out of 750 people (common)

13

How many cases are there of Parkinson's in the UK

100,000

14

Which other disease is Parkinson's more common than

Multiple sclerosis

15

What does the prevalence of Parkinson's increase with

Age
Reaching a max at about 70

16

Is Parkinson's an age related disease

Yes
But can get when young (40) but rare

17

How many new cases of Parkinson's are there each year in the UK

9000

18

List Parkinson's disease symptoms

- 4-8 Hz tremor of limbs
- rigidity of muscle tone
- difficulty initiating movement (akinesia)
- movements slow

19

When is tremor of limbs at its worst

When anxious and resting

20

When does tremor of limbs stop

When asleep

21

Why don't Parkinson's disease px blink much

Due to rigidity of muscle tone

22

How to Parkinson's patients appear due to difficulty initiating movement

Appear frozen

23

What do Parkinson's disease symptoms result in

- deadpan expression
- stooped shuffling gait (increased muscle tone in back)
- pill rolling (between fingers & forefingers)

24

What is the cause of Parkinson's disease

It is idiopathic (don't know what caused it)

25

Between which groups is Parkinson's disease equal

Male & female

26

What is Parkinson's disease characterised by a loss of

Dopamine producing cells in the substantia nigra of the basal ganglia

27

What is the substantia nigra

A black area visible on a cut section of the midbrain which produces dopamine

28

What does the substantia nigra produce

Dopamine

29

What is the basal ganglia

5 pairs of nuclei