Neurotransmission Flashcards

(36 cards)

0
Q

Inhibitory neurotransmitter

A

GABA
Glycine
Alpha 2 agonist

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1
Q

Excitatory neurotransmitter

A

Glutamate
Aspartate
Substance P

Acetylcholine 
Catecholamines (dop nor epi)

Serotonin
Histamine

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2
Q

Pain excitatory

A

Prostaglandin, serotonin, substance p, histamine

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3
Q

Pain inhibitory

A

Serotonin, norepinephrine, endogenous opioids

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4
Q

Norepinephrine

A

Energy, fight or flight

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5
Q

Dopamine

A

Pleasure, reward, motor control

Schizophrenia, Parkinson’s pathophysiology

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6
Q

Serotonin

A

Mood, satisfaction

SSRI for depression

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7
Q

Antixiolytics

A

Shut down Anxiety circuits by GABA stimulation

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8
Q

Flumazenil

A

Benzo antagonist for BDZ overdose

Block BDZs, zolpidem, lunesta

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9
Q

Picrotoxin

A

Block Cl- pore

Reverse barbiturate, benzo effects

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10
Q

Locus ceruleus

A

Source of NE neurons nonadrenergic

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11
Q

Raphe nuclei

A

Source if serotonergic neurons

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12
Q

Ramelteon

A

Melatonin receptor agonist

Hypnotic

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13
Q

Sonata, zolpidem (ambien)

A

Non BDZ structure hypnotic

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14
Q

Buspirone

A

Selective anti-anxiety

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15
Q

Drugs that produce depression

A

AMPT
Reserpine
Tetrabenazine

16
Q

Drugs that relieve depression

A

Amphetamines
Iproniazid (MAO inhibitors)
Imipramine (reuptake inhibitors)

17
Q

SSRI

A

Escitalopram, fluoxetine, sertraline

18
Q

SNRI

A

Fluoxetine (cymbalta)

Venlafaxine (Effexor)

19
Q

NDRI

20
Q

NRI

21
Q

Tricyclic antidepressant

A

First generation
Nortriptyline
Desipramine

Doxepin
Amitriptyline
Imipramine

22
Q

First generation antipsychotic

Dopamine antagonists

Sexual dysfunction
Extrapyramidal symptoms

A

Haloperidol
Chlorpromazine
Fluphenazine
Thioridazine

23
Q

Second generation antipsychotic

Metabolic side effects

A

Olanzapine
Quetiapine
Risperidone
Aripiprazole

24
Clozapine
For treatment resistant schizophrenia
25
Cationic site
Lysine
26
An ionic site
Glutamate
27
Hydrophobic site
Gly ala phenylala GAP
28
OCD
Clomipramine
29
Valproic acid
Mania
30
Steven Johnson syndrome
Carbamazepine | Lamotrigine - good for depression in bipolar
31
Mood stabilizer
Lithium Carbamazepine Valproic acid
32
Felbamate
Lennox gasteaut FN KAT F NMDA antagonist
33
Status epilepticus
Lorazepam
34
Topiramate
Seizures and alcohol abuse KAT kainate AMDA antagonist
35
Zonisamide
Sulfa allergy