Neurotransmitters 2

Question 1

Neuroendocrine cell associated with lung cancer

Answer 1

Kulchitsky cell

Question 2

Antibiotic contraindicated in MG

Answer 2

Aminoglycoside cause neuromuscular blockade

Question 3

Tests for MG

Answer 3

Edrophonium Tensilon test

Repetitive Nerve Stimulation (Jolly test) - decremental response

Question 4

Phenylalanine -> Tyrosine -> L dopa (tyrosine hydroxylase) -> dopamine (dopa decarboxylase)

Answer 4

Metabolism of Catecholamine

Question 5

Phenylalalnine -> Tyrosine by the enzyme

Answer 5

Phenyl Alanine Hydroxylase

Needs tetrahydrobiopterin

Question 6

Cofactor deficient in PKU

Answer 6

Tetrahydrobiopterin

Question 7

Black urine

Answer 7

Alkaptopnuria

Question 8

Phenylalanine hydroxylase disease

Answer 8

albinism

Question 9

Locus ceruleus neurotransmitter

Answer 9

NE

Question 10

Chromatin of pheochromocytoma

Answer 10

salt and pepper chromatin

Question 11

Medullary thyroid
Pheochromocytoma
Parathyroid

Answer 11

MEN2A

Sipple’s syndrome

Question 12

Clinical feature associated with Pheochromocytoma

Answer 12

Headache
Profuse sweating
Palpitations and tachycardia
Hypertension

Question 13

Tryptophan -> 5 hydroxytryptophan by tryptophan hydroxylase

5 hydroxytryptophan -> 5 hydroxytryptamine (serotonin) by enzyme 5 hydroxytryptamine decarboxylase

Answer 13

Serotonin metabolism

Question 14

Serotonin is secreted by

Answer 14

GI enterochromaffin cells (90%)
Platelets
Brain

Sythesized from tryptophan (in diet)

Question 15

Involved in mood, sleep, appetite, sex

Imbalance leads to depression and anxiety

Answer 15

Serotonin

Question 16

Role in anxiety / depression serotonin receptor

Answer 16

5HT-1A

Question 17

Role in migrane serotonin receptor

Answer 17

5HT-1D

Question 18

Role in nausea and vometing esp due to chemotherapy -> ondansetron

Serotonin receptor

Answer 18

5-HT3

Question 19

Carcinoid tumor chemotherapeutic drug

Answer 19

Capacetabine (Xeloda)
Doxorubicin
Streptozocin

Question 20

Streptozocin is best for

Answer 20

Insulinoma

Question 21

Treat depression, panic disorders, social phobia and depression with atypical features

Blocks MOA Enzyme responsible for breaking down tyramine

Selegeline

Answer 21

MAO inhibitors

Question 22

Glutamate -> GABA by enzyme

Answer 22

Glutamate decarboxylase

Question 23

Plays an important role in the body’s disposal of excess or waste nitrogen

Ammonia as ammonium is then excreted predominantly as urea synthesized in the liver

Answer 23

Glutamate

Question 24

Excess NT in ALS

Answer 24

Glutamate

SOD

Question 25

Inclusion body ALS

Answer 25

Bunina bodies

Question 26

ALS targets

Answer 26

anterior horn cells

Question 27

Blocks glutamatergic and NMDA receptors

Answer 27

Riluzole

Question 28

Injectable antioxidant free radical scavenger | ALS

Answer 28

Edaravone (Radicava)

Question 29

Parkinsonism | Dysautonomia

Answer 29

Multiple systems atrophy | Shy Drager Syndrome

Question 30

Parkinsonism Jack knife brain Dementia

Answer 30

Frontotemporal Dementia | Pick’s Disease

Question 31

Inclusion body in Alzheimer’s

Answer 31

Hiruna

Question 32

Toxin that blocks Na channel

Answer 32

Tetradotoxin | Saxitoxin

Question 33

Mackarel poison

Answer 33

Scromboid

Question 34

Toxin that blocks K channels of neuron

Answer 34

Tetraethylammonium

Question 35

Botulinum toxin acts on

Answer 35

SNAP 25 Synaptosomal association protein 25 - Botox A | Snare protein

Question 36

Toxin by algal bloom

Answer 36

Pfeisteria

Question 37

Depletes Ach

Answer 37

Hemicholinium

Question 38

Omega 3 fatty acid for dyslexia

Answer 38

ALA Alphalinolenic acid (dyslexia) EPA Eicosapentanoic acid DHA Docosahexaneoic acid

Question 39

Parinaud’s syndrome

Answer 39

Pinealoma