Neurotransmitters Flashcards Preview

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Flashcards in Neurotransmitters Deck (33):
1

cocaine

blocks dopamine reuptake, leading to enhanced dopamine (pleasure) signals

2

amphetamines

enter presynaptic neuron, enter dopamine-filled vesicles, allows release of dopamine through pores

increased HR, BP

3

ecstasy

increases serotonin

4

morphine

binds to receptors for endorphins

5

drug abuse involves

reward via mesolimbic pathway

6

drug addiction involves

activation beyond the mesolimbic pathway

7

reward pathway

dopamine from VTA to NAc

8

nucleus accumbens

pleasure area (NAc)

9

Ach: Primary postsynaptic effect

excitatory

10

Glutamate: : Primary postsynaptic effect

excitatory

11

GABA: : Primary postsynaptic effect

inhibitory

12

Glycine: Primary postsynaptic effect

inhibitory

13

Catecholamines: Primary postsynaptic effect

modulatory

14

Serotonin (5-HT): Primary postsynaptic effect

modulatory

15

Histamine:: Primary postsynaptic effect

modulatory

16

endocannabinoids: Primary postsynaptic effect

inhibits release of lipids

17

Ach: Precursor

choline + acetyl CoA

18

Glutamate: Precursor

glutamine

19

GABA: Precursor

glutamate

20

Glycine: Precursor

serine

21

Catecholamines: Precursor

tyrosine

22

Serotonin: Precursor

tryptophan

23

Histamine: Precursor

histidine

24

Ach: Removal mechanism

AChEase

25

Glutamate, GABA, Glycine: Removal mechanism

transporters

26

Neuropeptides: Removal mechanism

proteases

27

ACh: Major RLS enzyme

CAT

28

Glutamate: Major RLS enzyme

glutaminase

29

Glycine: Major RLS enzyme

phosphoserine

30

GABA: Major RLS enzyme

GAD

31

Catecholamines: Major RLS enzyme

tyrosine hydroxylase

32

Serotonin: Major RLS enzyme

tryptophan hydroxylase

33

Histamine: Major RLS enzyme

histidine decarboxylase