Neurotransmitters Flashcards
(106 cards)
___ deaths attributed to OD on synthetic opiods (fentynal) other than methadone
19k
What are the symptoms of dependence/withdrawal from cannabinoids?
Irritability
Stomach cramping
Chills
Cold sweats
Opiod peptides
Neuropeptides Metabotropic receptors DEATHS - 2010 16k - 2015 53k - 2016 64k
Parkinson’s
Loss of neurons in substantia nigra
Where do you find cannabinoid receptors?
Widespread throughout brain Motor system - depresses Feeding Pain Limbic system - mood, emotion hippocampus - memory
neurokinin A
metabotropic receptor - NK2
Septal nuclei
Sends axons to cortex and hippocampus
Where do you find norepinephrine in the brain
locus coeruleus - brainstem (CNS)
PNS - sympathetics
Subtantia nigra
Use dopamine
Project to cornate nucleus and potamin - MOTOR control
Parkinsons
Acetylcholine receptors
Nicotinic - ionotropic
Muscarinic - metabotropic (m1-5)
Is there abuse potential for cannabinoids?
yes
% of US use cannabinoids for non medical use
10%
glutamate is an amino acid and is ____
The principle excitatory NT in the CNS
locus coeruleus
In brainstem
Projects to limbic system, cortex, spinal cord
Cannabinoid receptors
CB1, CB2
Metabotropic
6 protein coupled
Inhibit voltage gated Ca channels and transmitter release
How can cannabinoids be used to tx hyperalgesia
Receptors located on PERIPHERAL nerves
Local administration at side of injury/inflammation can decrease hyperalgesia
Aspartate is an amino acid that acts as a ______ neurotransmitter
excitatory
norepinephrine receptors
metabotropic - alpha, beta
Chronic pain can be caused by the loss of neurons that contain which amino acid?
GABA
Glutamate (excitatory) has what kind of receptors?
ionotropic
metabotropic
GABA has what kind of receptors?
ionotropic
metabotropic
Do cannabinoids have reinforcing properties?
yes
Function of norepinephrine
Mood - depression
panic
responses to stress
Ionotropic glutamate receptors bind…
AMPA
Kainate
NMDA