Non-Infectious Inflammatory Diseases Flashcards Preview

Pulmonology 2 > Non-Infectious Inflammatory Diseases > Flashcards

Flashcards in Non-Infectious Inflammatory Diseases Deck (23):
1

What is Sarcoidosis?

A multisystem granulomatous disease of unknown etiology

2

Who does sarcoidosis affect?

(young and middle aged adults)
No gender difference
African american and caucasians
Have had past exposure to insectisides, agric. employment, and microbial bioaerosols

3

What is the clinical presentation of sarcoidosis?

Most commonly: Lung involvement
Uveo-parotid fever = Heerford's syndrome

Erythema nodosum
Polyarthralgia
Bilateral Hilar lymphadenopathy
=Lofgren's syndrome

4

How can diseases similar to Sarcoidosis be ruled out? Tests?

History
-symptoms
-occ exposure
PE: adenopathy, skin lesions,
PFTs
Labs: Ca level, liver Ez, creatinine
ECG
Opthalmologic eval
TB skin test

5

WHat is seen on the Pulmonary Function test in Sarcoidosis?

Restrictive: Normal shape with smaller volumes
Dec Total Lung Capacity
Dec Vital Capacity
Dec Rreserve Volume
Dec Diffusion Capacity (CO)

6

What is the appearance of the stages of development of Sarcoidosis on CXR?

Stage 1: Hilum
St 2: consolidation(haziness)
St 3: no lymphadenopathy only infiltrates
St 4: Extensive fibrotic Change in lung

7

What is the appearance of Sarcoidosis on Chest CT?

Granulomas

8

What are the diagnositic procedures used for Sarcoidosis?

Bronchoscopy
BAL(broncho-alveolar lavage):
Endo/transbronchial biopsies

9

What is the treatment of Sarcoidosis?

Systemic Corticosteroids in systemic involvement
Methotrexate
Azathioprene
Hydroxichloroquine

10

What are the connective tissue diseases that can effect the lungs?

RA
Scleroderma
SLE
Sjogren Synd
Dermatomyositis and polymyositis

11

What is the presentation of Rheumatoid lung diasease?

Non-productive cough
Dyspnea on exertion
Clubbing
-fine crackles
-pleural rub

May precede joint disease by years

12

What medications are used for Rheumatoid lung diasease?

Methotrexate
Etanercept
Infliximab

13

What is the most common cause of death in Scleroderma?

Pulmonary fibrosis

14

What are the different presentations of scleroderma?

Diffuse scleroderma
Interstitial Lung disease

Limited form(CREST Syndrome)
Pulmonary Htn
Dec DLCO

15

What is included in CREST syndrome?

Calcinosis
Raynaud's
Esophageal Dysmotility
Sclerodactyly
Telangectasia

16

What is seen in Pulmonary involvement of SLE?

Serositis
Acute and Chronic Lupus Pneumonitis
Alveolar Hemmorhage
Diaphregmatic Dysfunction
Increased risk for DVT/PE

17

What is the Presentaion of Sjogren's syndrome in the lung?

Airway compromise
Bronchiectasis and bronchiolitis

18

How can you tell if an airway is dilated on CT?

The airway is wider than the BV that runs with it.

19

What is the presentation of Pulmonary Vasculitis?

Wegener's granulomatosis
Churg Strauss synd
Diffuse Alveolar hemmorhage
Goodpasture's synd

20

How is wegener's granulomatosis differentiated from TB?

Serology

21

What is seen in CXR of Goodpasture's syndrome?

Bleeding from Alveoli
Need to do bronchoscopy

22

What is the Triad seen in Churg Strause Syndrome?

Asthma, hypereosinophelia, necrotizing vasculitis

23

What is seen on Spirometry in Churg-Strauss Synd?

Similar to asthma