Flashcards in Pathology of Lung Cancer Deck (23):
What are the methods for diagnosis of Lung masses?
Bronchial lavage, brushing
What are the most common causes of Coin lesions in the lung?
Chronic Pneumonia and abcess
What is the most common malignant cancer of the lung?
What are the top 4 causes of Pleural Exudates?
What are the most common Paraneoplastic syndromes from lung cancer?
What are Systemic manifestations of Lung cancer?
Lambert Eaton myasthenic Synd: muscle weakness
Peripheral neuropathy: sensory only
Acanthosis Nigricans: dermatologic
Leukemoid reactions: hematologic
What is a Pancoast Tumor?
Direct growth of tumor from lung apex into brachial plexus
8th cervical thoracic nerves
Horner synd: enopthalmous, ptosis, miosis, and anhidrosis
What causes Superior VC Syndrome?
Tumor inpinges on Superior VC.
Causes blood to back up into the upper body
What are common risk factors for lung cancer?
SMOKING(2nd hand too)
What are the different types of Non-small cell CA?
Squamous cell CA
Large Cell CA
Waht are the most common gene mutations seen in AdenoCA?
Squamous cell CA?
KRAS and EGFR mutations
p53, RB1, p16
What are the 2 types of AdenoCA?
Bronchial Derived and Bronchioloalveolar
What is bronchoalveolar CA?
Grows along pre-existing Alveolar Walls, preserves architecture, lepidic
Mucinous and non-mucinous
What is the progression seen in Squamous cell CA?
Metaplasia > Dysplasia > CIS > Invasive CA
What are the Mutations associated with Small Cell CA?
c-MYC and RB1
How is Small Cell CA treated?
Chemo works well against rapidly dividing cells. mean survival is 1 year.
What stain is used in Identifying Sq Cell CA?
Papanicolaou (pumpernickle?) stain turns keratin red.
What is charicteristic of Large Cell CA?
Anaplastic(large, irregular looking cells)
Poor prognosis, metastasizes early
What are secondary pathologies related to lung cancer?
Change occurs distal to the tumor
Partial obstruction: focal emphasema(total: atelectasis)
Severe bronchitis, bronchiectasis, pulmonary abcess
Post obstructive Pneumonia
What are the most common causes of death in Lung Cancer?
Effects of metastases on other organs
What are the different Neuroendocrine Tumors associated with lung cancer?
What are the different pleural tumors?
Benign- pleural fibroma (benign mesothelioma)
Malignant- Malg. Mesothelioma