Normal Microbiota Flashcards

1
Q

define colonisation

A

establishment at a site in the body

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2
Q

define microbiota

A

all the organisms in a given community

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3
Q

define microbiom

A

all the genes present within microbiota

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4
Q

what is symbiosis

A

two or more organisms living or co-existing in close physical association

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5
Q

what are the 4 types of symbiosis

A

mutualism - both organism benefit
neutralism - neither benefit nor harm
commensalism - one organism benefits the other derives no benefit or harm
parasitism - one rogasnim benefits at the expense of the other

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6
Q

how can non-sterile environments be contaminated

A

directly through the skin or indirectly such as through trachea or GI tract

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7
Q

how are sterile sites in the body kept that way with examples

A

surface cleaning - eg lower RT uses sputum to trap MO’s
OR barriers
OR physical operation (pleural cavity)

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8
Q

define tropism

A

propensity for an organism to grow in that particular habitat

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9
Q

what does a tropism depend on

A

moisture, temp, ph, O2, nature of surface

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10
Q

which microbes are normally found on the skin

A

staphylococcus epidermis/aureus and other coagulase negative staphylococcus
propionbacterum such as (acnes)

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11
Q

what kind of environment does the skin provide

A

variable temperature, dry, subject to abrasion, aerobic. nutrient poor

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12
Q

what kind of environment is gingival crevice

A

constant temp, moist, aerobic, lots of nutrients

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13
Q

what microbiom are present in gingival crevice

A

viridian’s streptococci

anaerobes (clostridium)

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14
Q

what relationships are there between the bacteria and host in the gingival crevice

A

mutualistic (both gain) and/or parasitic (one gain other loses)

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15
Q

what microbiom are usually present in the nose and pharynx

A
s. aureus (nose) 
pharynx - streptococcus pyogenes 
haemophilus influenza 
streptococcus pneumonia 
niesserira meningitis 
s.aureus
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16
Q

what microbiom are present in the vagina before and after puberty

A

before - same as skin flora and lower GIT (e.coli)
after - glycogen produced and nutrient rich = lactobacillus (mutualistic)
skin flora
candida albicans (can lead to thrush in higher pH)

17
Q

what microbiom are present in the stomach and small intestine

A

low gastric pH inhibits bacterial growth

mostly aerobic or acid tolerant such as lactobacilli or h pylori

18
Q

what microbiom are present in the large intestine

A

95-99% anaerobes (clostridium spp, bacteriedes spp)
aerobic bacteria - gram negative bacilli (escherichia coli)
overgrowth of c. difficile

19
Q

what is toxic megacolon and what is the treatment

A

infection by clostridium difficile - antibiotic resistant colitis
faecal transplant - introduce normal flora

20
Q

what are the benefits of normal flora

A

metabolism - synthesis metabolites such as vit K and B12 - eneertic bacteria in the gut

resistance against colonisation

protective effects - cross reactive antibodies

nitric oxide production - vascular health

acetate, propionate production - inhibit growth of enteropathogens

21
Q

which disease is commonly linked with unhealthily gut flora (primary granulomatous disease)

A

crohns disease

22
Q

what are the three pathological steps of normal flora

A

overgrowth

translocation - presence at the wrong site (endogenous infection)

23
Q

what is exogenous infection

A

cross infection from other people

24
Q

what is latent infection

A

pathological organism is present but doesn’t cause disease