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Class: Immuno Block > NSAID > Flashcards

Flashcards in NSAID Deck (4)
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1

COX-1

1) TXA-2: Vasoconstrictive, pro-coagulant
2) House-keeping PGE2: Gastric mucosa

2

COX-2

Major inflammatory enzyme
1) PGI2 - prostacyclins
2) PGE2 - inflammation

3

Platelets express which COX?

Express COX-1 and NOT COX-2

4

Aspirin

1) Acetylates COX-1 Irreversible inhibitor -> INACTIVATES COX-1 for cell's lifetime = anti-inflammatory
BLOCKS COX-1 in platelets -> anti-coagulant + platelets do not have nuclei to make more COX-1
2) Acetylates COX-2 -> Generates anti-inflammatory agent