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Flashcards in Immuno Exam Questions Deck (25)
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1
Q

Region in the variable domain of protein in the Ig Sperfamily + TCR
Less variable than Complementarity determining region

A

Framework region

2
Q

Part of variable chains in Igs and TCR (Ag-specific)

A

Complementarity Determining Region

3
Q

Somatic mutation of VDJ DNA segments allows single B cell to produce Igs of different

A

IDIOTYPE
Idiotype - Actual Ag binding site OR variable region sequence outside of the Ag binding site on Ab
Each Ab has multiple idiotopes. Set of these idiotopes = Idiotype of Ab

4
Q

Splicing of VDJ segments for Ig heavy chains occurs ___

A

Bone marrow

5
Q

Somatic hypermutation of Fab AND class switching (gene splicing) in Igs occur in ___

A

Lymph node germinal center

6
Q

Splicing of T cell receptor genes (VDJ genes) to produce receptor specific for Ag peptide/MHC [functional TCR] occurs ___

A

Thymic cortex

7
Q

After complete Ig heavy chain assembly, V/D and D/J splice junctions are found in

A

Complementarity determining regions (CDR)

8
Q

Class switching of Abs

(e.g. immature B cell making both IgM/IgD -> mature B cell only produces IgM) occurs from which molecular mechanism?

A

Differences in mRNA splicing of DNA encoding Ig constant regions

9
Q

RAG-1/RAG-2 complex cleaves two sequences simultaneously of what pattern

A

Sequence 1: Conserved “7-9bp” with 12-bp spacer

Sequence 2: Conserved “7-9bp” with 23-bp spacer

10
Q

Which process is responsible for viral infection-related joint pain, malaise (general feeling bad), loss of appetite, fever, sleepiness

A

Cytokine release from monoyctes/T cells

11
Q

Granulomas are predominantly made of _

A

T cells and macrophages (Type IV Hypersensitivity)

12
Q

Ab property that measures the likelihood of the Ag binding

A

AFFINITY

Measure by Fab fragments + hapten

13
Q

Ab property that shows strength of Ag binding (“least likely to dissociate from Ab”)

A

AVIDITY
Measure by ([Fab’]2 fragments + carrier which has multiple haptens bound])
HIGH SURFACE AREA and HIGH # of Ags bound
IgM has higher avidity and IgG has higher affinity

14
Q

Epitope and Ab paratope interaction

A

AA residues of paratope interact with eptiope via MULTIPLE NON-COVALENT BONDS

15
Q

IgG Fab

A

1) Bind to Ag
2) NO CROSSLINKING of Ag
3) DOES NOT activate complement via classical pathway [Fc of IgG binds C1qrs]

16
Q

Form of vaccine that is safe to administer to someone with immunodeficiency

A

Killed virus

17
Q

Form of vaccine that needs refrigeration during transport, one dose can provide protective immunity, risk of paralytic disease, contacts of vaccine can be vaccinated

A

Live attenuated vaccine

18
Q

When an immune response occurs in the lymph node, dividing B cells are located in the _

A

Germinal Centers

19
Q

CTL Pathway in which CTLs SECRETE serine proteases that induce cell apoptosis, kill bacteria, inhibit viral replication

A

Perforin/granzyme pathway

20
Q

CTL pathway involving interaction between membrane receptors between CTL and target cell
**Fas ligand (TNF family member) on CTLs bind to Fas receptor (Death receptor) on target cells -> Induce apoptosis

A

Fas/Fas ligand pathway

21
Q

Hematopoetin/IFN cytokines bind to PM receptors and activate __

A

Protein kinase

22
Q

TCRs contain only ONE site of what?

A

Ag binding

23
Q

These cells have receptors that are capable of binding INTACT viral proteins

A

B cells (Th independent activation of B cells)

24
Q

Drugs most effective for treatment of patients with CHRONIC conditions (e.g. asthma/bronchial hyperresponsiveness)

A

Corticosteroids (Glucocorticoid)

25
Q

Chains Produced by B cells in Peyer Patches

A

Alpha, Kappa chains (IgA kappa)