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Flashcards in Immuno Exam Questions Deck (25)
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1

Region in the variable domain of protein in the Ig Sperfamily + TCR
Less variable than Complementarity determining region

Framework region

2

Part of variable chains in Igs and TCR (Ag-specific)

Complementarity Determining Region

3

Somatic mutation of VDJ DNA segments allows single B cell to produce Igs of different

IDIOTYPE
Idiotype - Actual Ag binding site OR variable region sequence outside of the Ag binding site on Ab
Each Ab has multiple idiotopes. Set of these idiotopes = Idiotype of Ab

4

Splicing of VDJ segments for Ig heavy chains occurs ___

Bone marrow

5

Somatic hypermutation of Fab AND class switching (gene splicing) in Igs occur in ___

Lymph node germinal center

6

Splicing of T cell receptor genes (VDJ genes) to produce receptor specific for Ag peptide/MHC [functional TCR] occurs ___

Thymic cortex

7

After complete Ig heavy chain assembly, V/D and D/J splice junctions are found in

Complementarity determining regions (CDR)

8

Class switching of Abs
(e.g. immature B cell making both IgM/IgD -> mature B cell only produces IgM) occurs from which molecular mechanism?

Differences in mRNA splicing of DNA encoding Ig constant regions

9

RAG-1/RAG-2 complex cleaves two sequences simultaneously of what pattern

Sequence 1: Conserved "7-9bp" with 12-bp spacer
Sequence 2: Conserved "7-9bp" with 23-bp spacer

10

Which process is responsible for viral infection-related joint pain, malaise (general feeling bad), loss of appetite, fever, sleepiness

Cytokine release from monoyctes/T cells

11

Granulomas are predominantly made of _

T cells and macrophages (Type IV Hypersensitivity)

12

Ab property that measures the likelihood of the Ag binding

AFFINITY
(Measure by Fab fragments + hapten)

13

Ab property that shows strength of Ag binding ("least likely to dissociate from Ab")

AVIDITY
Measure by ([Fab']2 fragments + carrier which has multiple haptens bound])
HIGH SURFACE AREA and HIGH # of Ags bound
**IgM has higher avidity and IgG has higher affinity**

14

Epitope and Ab paratope interaction

AA residues of paratope interact with eptiope via MULTIPLE NON-COVALENT BONDS

15

IgG Fab

1) Bind to Ag
2) NO CROSSLINKING of Ag
3) DOES NOT activate complement via classical pathway [Fc of IgG binds C1qrs]

16

Form of vaccine that is safe to administer to someone with immunodeficiency

Killed virus

17

Form of vaccine that needs refrigeration during transport, one dose can provide protective immunity, risk of paralytic disease, contacts of vaccine can be vaccinated

Live attenuated vaccine

18

When an immune response occurs in the lymph node, dividing B cells are located in the _

Germinal Centers

19

CTL Pathway in which CTLs SECRETE serine proteases that induce cell apoptosis, kill bacteria, inhibit viral replication

Perforin/granzyme pathway

20

CTL pathway involving interaction between membrane receptors between CTL and target cell
**Fas ligand (TNF family member) on CTLs bind to Fas receptor (Death receptor) on target cells -> Induce apoptosis

Fas/Fas ligand pathway

21

Hematopoetin/IFN cytokines bind to PM receptors and activate __

Protein kinase

22

TCRs contain only ONE site of what?

Ag binding

23

These cells have receptors that are capable of binding INTACT viral proteins

B cells (Th independent activation of B cells)

24

Drugs most effective for treatment of patients with CHRONIC conditions (e.g. asthma/bronchial hyperresponsiveness)

Corticosteroids (Glucocorticoid)

25

Chains Produced by B cells in Peyer Patches

Alpha, Kappa chains (IgA kappa)