Eicosanoids Flashcards Preview

Class: Immuno Block > Eicosanoids > Flashcards

Flashcards in Eicosanoids Deck (11)
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1

PGI2 (Prostacyclin)

Produced by vascular endothelium, Vasodilation, INHIBITS clot formation

2

PGE2, PGF2

Vasodilation, INHIBITS clot formation, promotes uterine smooth muscle contraction

3

Leukotriene B4

Major chemotactic factor for leukocytes (neutrophils)

4

PGE

Prostaglandin important for protecting gastric mucosa - INCREASE MUCOUS secretion/ DECREASE GASTRIC acid secretion

5

-sone's (cortisone, hydrocortisone, prednisolone, methylprednisolone, dexamethasone, betamethasone)

Glucocorticoid therapy - Blocks phosphlipaseA2, blocks immune cell activation (macrophages/mast cells)

6

Metabolic Adverse effects of Glucocorticoid therapy

INCREASED Serum Glc (Stimulates gluconeogenesis, glycogenesis, inhibits Glc uptake in muscle cells), INCREASED fatty acid levels/fat acid deposition (Stimulates hormone-sensitive lipase mediated lipolysis), INCREASED protein catabolism (muscle wasting)

7

Other Adverse effects of Glucocorticoid therapy

OSTEOPOROSIS, CUSHING'S SYNDROME (Moon face), HYPERTENSION, edema, GLAUCOMA/cataracts, poor wound healing, susceptible to bacterial/opportunistic infections, peptic ulcers, CNS DEFECTS

8

Other Actions of Cortisol

Blocks Vitamin D's Action on Calcium Absorption
90% of the time bound to Corticosteroid Binding Protein
Least pronounced after meals - since gluconeogenesis, glycogenesis, lipolysis will be stimulated under starvation conditions NOT fed state

9

Prednisone

Prodrug activated by 11-betahydroxysteroid dehydrogenase that reduces the 11-beta keto group to hydroxyl group

10

Triamcinolone acetonide

Enhanced topical activity relative to the underivatized drug

11

TXA2

Produced by platelets, COX1, Vasoconstrictor, PROMOTES platelet aggregation (CLOT FORMATION)