Anti-Cytokine Drugs Flashcards Preview

Class: Immuno Block > Anti-Cytokine Drugs > Flashcards

Flashcards in Anti-Cytokine Drugs Deck (11)
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1

1) IMP dehydrogenase inhibitor
2) Prevents de novo purine biosynthesis

Mycophenolate Mofetil

2

1) Prevents lymphocyte proliferation
2) Anti-inflammatory

Leflunomide, Methotrexate (DHTF reductase inhibitor)

3

mAB against BAFF/BLYS [B cell activating factor]
BAFF (member of TNF family) = key determinant for B cell survival during tolerance dvlm -> Promote B cell survival and proliferation

Belimumab

4

Treatment against lupus (overactive B cells)

Belimumab

5

Anti-CD3 Ab (T cell marker) -
1) Used to prevent kidney/liver/heart organ rejection
2) Used to deplete donor T cells from bone marrow pre-bone marrow Tx to prevent GvHD

Muromonab

6

Anti-IL2 Ab (Competitive inhibitor)
Used to prevent acute rejection post-kidney Tx

Dacluzimab

7

anti-IL17 mAb
Used to treat psoriasis

Secukinumab

8

anti-IgE mAb
Used to treat asthma potentially

Omalizumab

9

anti-TNFalpha mAbs
Used against autoimmune diseases (e.g. Crohn's, rheumatoid arthritis)

Infliximab
Etanercept
Adalimumab
Certolizumab

10

Cytokine used for hepatitis C treatment

IFN-alpha

11

1) Nucleoside Analog - BLOCKS Replication
2) BLOCKS de novo purine biosynthesis
Blocks T cell proliferation and IL proliferation

Azathioprine