Mucosal Immunology Flashcards Preview

Class: Immuno Block > Mucosal Immunology > Flashcards

Flashcards in Mucosal Immunology Deck (11)
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1

T cell marker that upregulates Th1 (present in the lamina propria) - specific to the gut

CD70

2

Signaling molecule released by DC that direct T cells to effector tissue

RA -> a4b7 + CCR9

3

Effector Tissue Layers of the Gut

Intraepithelial Cells (Induced and Natural) - CD8+
Lamina Propria - CD4+ (Th1 and Treg)

4

Chemokine Receptor on the DC that actively participates in Ag capture from the gut lumen

CXCR3+ DCs

5

Anti-inflammatory cytokines that decrease permeability (GOOD)

IL-10
TGF-beta

6

Pro-inflammatory cytokines that increase permeability (BAD)

TNF-alpha
IFN-gamma
IL-13

7

Dietary molecule that increases permeability

Glc

8

Diff between iELs and nIELs

iELs - Rapidly activated to mediate attack on incoming pathogens [NOT directly recruited to gut -> Migrates through Peyer's + Mesenteric lymph nodes]
nIELs - Maintain epithelial HOMEOSTASIS (maintenance and repair) by producing TGFbeta [DIRECTLY recruited to gut]

9

Asthma is what Th response?

Amplified Th2 responses + Enhanced mast cell activity

10

COPD is what response?

Th1 + Apoptotic Epithelial Cell deregulation

11

Marker on T cell that upregulates Treg

CD103