Immunosuppressants Flashcards Preview

Class: Immuno Block > Immunosuppressants > Flashcards

Flashcards in Immunosuppressants Deck (11)
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1

Toxicities of sirolimus (rapamycin)

Hyperlipidemia, Anemia, Leukopenia, Thrombocytopenia, Fever, GI effects

2

CyclosporineA

1) BLOCKS calcineurin (phosphatase) -> Activates Tx of IL-2R genes
Acts on T cells to inhibit TCR activation and Cytokine Induction
2) BLOCKS IgE mediated mast cell degranulation
3) STIMULATES TGF-beta expression: Inhibitory cytokine
**KIDNEY TOXICITY

3

Tacrolimus (FK506)

BLOCKS calcineurin used for IL-2R Tx activation
Acts on T cells to inhibit TCR activation and induction of cytokines
FKBP/FK506 Complex binds to and blocks calcineurin
**Same action as CsA but used as an alternative since it does not have kidney toxicity

4

Two drugs that can bind to FKBP12 to prevent action of calcineurin

Tacrolimus (FK506)
Sirolimus (rapamycin)

5

Tacrolimus

FK506

6

Sirolimus

Rapamycin

7

Two drugs that block calcineurin

CsA + Tacrolimus (FK506)

8

Immunosuppressant Drugs that blocks T cell proliferation (IL-2)

1) mTOR inhibitors (Sirolimus and Everolimus)
2) Cytotoxic Drugs that inhibit Purine biosynthesis (Azathioprine, Mycophenolate Mofetil)
3) Dacluizmab - Prevents binding of IL-2 to its receptor

9

Drug (acts like CTLA4-IgG) - Binds CD80(B7)/CD86 [APC] and prevents it from binding to CD28 (Tcell)

Abatacept [CTLA4-IgG]

10

Another R.A. drug that acts as an anti-TNFalpha agent

Adalimumab (Humira)

11

Sirolimus (Rapamycin)

T cell blocker by BLOCKING mTOR kinase (Needed for cytokine signaling)
Prophylaxis of organ rejection
Used with Calcineurin inhibitors and glucocorticoids