nuclear hormone receptors

Question 1

function of transactive domain?

Answer 1

allows conformational change
change in DNA initiates transcription

Question 2

function of DNA-binding/dimerization domain?

Answer 2

allows dimerization of receptors and binding to DNA

Question 3

function of nuclear localisation domain?

Answer 3

allows receptor to enter nucleus

Question 4

characteristic of steroid hormones?

Answer 4

lipid soluble
small, pass through membrane
slower acting

Question 5

characteristic of non-steroid hormones?

Answer 5

water soluble
faster acting

Question 6

what do steroid hormones bind to?

Answer 6

intracellular receptor

Question 7

what do steroid hormones activate?

Answer 7

genes to produce new proteins

Question 8

what do non-steroid hormones bind to?

Answer 8

receptors on target cell membranes

Question 9

what do non-steroid hormones activate?

Answer 9

pathways that produce 2nd messengers
activate existing enzymes