Nucleus Flashcards
(21 cards)
nucleoid
region of prokaryotes where chromosomes are located
nucleoplasm
- fluid-filled interior of nucleous
- 30 subdomains
nucleolus
- irregular shape
- produce ribosome
transcription factories
- active genes form diff subdomains extend interchromosomal channels to form tubes
- transcription factors are concerited
nuclear speckle
- MRNA splicing factories concentrated here
- in interchromosomal channels
nuclear matrix
- protein mesh
- nucleoplasm
cytoskeleton
- microfilaments
- microtubules
- Intermediate filaments
nuclear envelope
- separates contents of the nucleus from the surrounding cytoplasm
- acts as a barrier
nuclear lamina
- inner surface of nuclear inner membrane
- mesh network provides support
nuclear pore complex
- channel;s in nuclear envelope
- regulation
- small polar molecules
central scafolding
- composed of integral/trans membrane-bound neucleoporins
- forms aqueous central channel
y complex (cytoplasmic and nuclear rings)
composed of nups
cytoplasmic filaments
- long nup extend into cytoplasm
- nuclear receptor cargo protein recognition
- import from cytoplasm
nuclear basket
- nuclear receptor cargo protein import and export to cytoplasm
nuclear localization signals (NLS)
AA sequence that is both necessary and sufficient for cytoplasm to nuclear targeting
- classic: common, short stretch + charge
- bipartite: two short stretch AA 7-10 AA long spacer
karyofarins
large family of receptor proteins responsible for moving macromolecules into nucleous or out
cyclin
nucleocytoplasmic proteins involved in cpontrol of cell cycle
interphase
- G1
- S DNA replication sythesis
- G2 prep for mitosis
- Go most cells
Mphase
miosis
cytokensis
CDKs
cell cycle-specific kinase enzymes located in the nucleus phosphorylate various target proteins
open mitosis
nuclear structure during mitosis
