Nutrition Module 11: CVD - Lipoproteins Flashcards Preview

SMP - MNE Exam 2 > Nutrition Module 11: CVD - Lipoproteins > Flashcards

Flashcards in Nutrition Module 11: CVD - Lipoproteins Deck (55)
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What 4 foods are flavonoids in?

1. Fruits
2. Vegetables
3. Wine
4. Tea


What are 2 viscous fibers?

1. Pectin
2. Beta-glucan


What is a genetic factor that increases responsiveness to dietary cholesterol?

Apolipoprotein E4


What kind of FA is myristic FA?

Saturated FA


How does the raise in LDL due to saturated FAs compare to the lowering in LDL due to polyunsaturated FAs?

Raise is bigger


What are polyunsaturated FAs susceptible to? What does this cause?

Peroxidation making them more atherogenic and causing a chain of free radical and lipid hydroperoxide synthesis


Which lipoproteins are most susceptible to peroxidation? Why?

LDLs because of high polyunsaturated FA content


Why do some people with excess iron stores have increased CVD and cancer risks?

Because the generation of most toxic free radicals is catalyzed by free Fe Copper


What happens to oxidized LDLs?

They are no longer recognized by their normal receptors but bind to the scavenger receptor on macrophages (which become foam cells) and other cells to promote atherosclerosis


What can explain why antioxidants in fruits and veggies are more effective than those in supplements in preventing disease? 1 example?

Because antioxidants are interdependent and complimentary

Eg: ascorbic acid regenerates alpha-tocopherol inhibiting it from becoming a pro-oxidant


What are normal HDL levels?

40 and above in men
50 and above in women


What are the 4 main functions of HDLs?

1. Transfer apoC-II and apoE to chylomicrons and VLDLs to regulate them
2. Take up cholesterol and phospholipids from VLDLs and LDLs
3. Remove cholesterol from tissues


What are the 2 types of factors influencing HDL levels?

1. Constitutional factors
2. Lifestyle factors


What are the 3 constitutional factors of HDL levels?

1. Sex: women have higher levels
2. Genes
3. Hormonal status: decrease after menopause


What are the 3 lifestyle factors of HDL levels?

1. PA
2. Weight
3. Alcohol (moderate intake increases HDL)


What are the primary prevention guidelines for CVD?

1. Maintain healthy weight
2. Sat fat intake below 10% of calories and low trans fats
3. Cholesterol intake below 300 mg/day
4. 2 servings of fish/week
5. Fruits/veggies
6. Whole grains and high fiber foods
7. Salt intake below 6g aka 2300 mg
8. Alcohol limits to 2 a day for men and 1 for women
9. Limited foods/drinks with added sugar


What are the 2 FAs with the greatest cholesterol-raising potential? Foods high in these?

Myristic and palmitic acid in butter, whole milk, cream and high-fat cheeses


Which affect serum cholesterol levels the most: types of FAs consumed or dietary cholesterol?

Types of FAs


Which have more unsaturated FAs: liquid or solid fats?

Liquid oils


Which lipoprotein delivers dietary cholesterol to the liver?

Chylomicron remnants


What are the most reversible vascular lesions?

Fatty streaks


Can carbs increase LDL levels?



What will usually raise LDL levels?

Excessive VLDLs


What can raise VLDL levels?

Reduced fat intake because VLDLs are needed to transport TAGs and cholesterol within the body


What is cholestasis? What is it caused by?

Stopped bile flow caused by absence of CKK