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BPT annoying facts > Oncology 2 > Flashcards

Oncology 2 Flashcards

1
Q

Commonest cause of SVC obstruction syndrome?

A

NSCLC

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2
Q

Ki67 expressions is what?

A

Cancer - cell proliferation

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3
Q

Ki67 is not expressed in what stage of cell cycle?

A

G0

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4
Q

Most significant prognostic risk factor for early breast cancer?

A

number of Lymph nodes involved

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5
Q

Most aggressive type of breast cancer?

A

Triple negative - basal like

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6
Q

How tamoxifen causes VTE?

A

Inhibition of anti-thrombin III

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7
Q

Aromatase inhibitor tend to cause what?

A

Osteoporosis- higher fracture risk

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8
Q

Younger than <50 years old - screen for breast cancer use what imaging and why?

A

US/ MRI breast- tissue denser

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9
Q

Most common breast cancer subtype?

A

DCIS

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10
Q

High risk factors for breast cancer?

A

Triple negative
High Ki67
HER2+

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11
Q

Bone mets in breast cancer prognosis?

Organ mets in breast cancer prognosis?

A

Bone - years

Organ - months

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12
Q

ER/PR positive breast cancer treatment? (in progression)

A

1st line Hormone therapy ( AI/ Tamoxifen)
2nd line - (AI)
3rd line - mTORI inhibitor - Everolimus + Examestane

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13
Q

HER2+ breast cancer treatment

A

1st line - Transtuzumab ( + rapidly progressive cancer)
IF relapse after > 6 months = Transtuzumab + Pertuzumab + Chemotherapy

IF relapse after < 6 months = Lapatinib ( cross BBB - for brain mets)

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14
Q

Bone mets from breast cancer management?

A

Denosumab best

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15
Q

When add chemotherapy in breast cancer?

A

LN involved + high risk factors for breast cancer present

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16
Q

When add radiotherapy in breast cancer?

A

Tumor > 4 cm and 4 LN positive

17
Q

Endometrial cancer is what histology subtype?

A

Adenocarcinoma

18
Q

Docetaxel side effect?

Cabazitaxel side effect?

A

Neutropenic sepsis/ peripheral neuropathy

Neutropenia/diarrhea

19
Q

VHL gene does what?

A

Keeps HIF in check

20
Q

Commonest cancer in Australia

A

1st - Breast cancer

2nd - CRC

21
Q

Brains mets from what cancer commonly have ICH?

A

Melanoma
Thyroid
Renal cell carcinoma

22
Q

Right sided Colorectal comes from ?

Left sided Colorectal comes from?

A

Right - Midgut

Left - hindgut

23
Q

Immunochemistry staining specific for melanoma?

A

S100 and Melan-A

24
Q

CRC expresses what receptor?

A

Cox2 receptor - so use aspirin

25
Q

Oesophageal Cancer -Adenocarcinoma type
Protective?
Risk factor?

A

Protective - H. pylori

Risk factor - Barret’s, GORD

26
Q

Oesophageal Cancer - SCC type
Protective?
Risk factors?

A

Protective - Smoking/ETOH/HPV

Risk factors - p16+ve

27
Q

Cetuximab/panitumumab side effect?

A

Acneiform rash
Hypomagnesium
Diarrhea

28
Q

Erlotinib side effect?

A

Pulmonary toxicity
Hepatic derangement
Skin rash - tx with doxycyline

29
Q

Osimertinib side effect?

A

Prolonged QTc

30
Q

When use CDK4/6?

A

Luminal subtype of breast cancer

BPT annoying facts (62 decks)

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