One Liners Set 01

Question 1

Time it takes for amount of drug to fall to half of its value, constant in first order kinetics (majority of drugs)

Answer 1

Half Life (T 1/2)

Question 2

Inducers of CYP450

Answer 2

Barbiturates
Carbamazepine
Phenytoin
Rifampin

Question 3

Inhibitors of CYP450

Answer 3

Cimetidine
Grapefruit
Isoniazid
Ketoconazole

Question 4

Ability of drug to produce the maximal biologic effect

Answer 4

Efficacy

Question 5

Steroids’ MOA:

Answer 5

Utilizes intracellular receptors

Question 6

Insulin, EGF, TGFbeta, PDGF, ANP common MOA:

Answer 6

Uses Transmembrane Receptors with Intrinsic Enzymatic Activity

Question 7

Antidotes used for organophosphate/anticholinesterase poisoning

Answer 7

Atropine
Pralidoxime (2-PAM)

Question 8

Antidote for acetaminophen (APAP) toxicity

Answer 8

N-acetylcysteine

Question 9

Antidote for heparin toxicity

Answer 9

Protamine Sulfate

Question 10

Antidotes for warfarin toxicity

Answer 10

Fresh Frozen Plasma (FFP) and Vitamin K

Question 11

Antidote for tissue plasminogen activator (t-PA) or Streptokinase

Answer 11

Amino-caproic Acid

Question 12

Antidote for opioid toxicity

Answer 12

Naloxone [NARCAN] (IV)

Naltrexone (PO)

Question 13

Antidote for Benzodiazepine toxicity (antagonist that reverses CNS effects)

Answer 13

Flumazenil

Question 14

You must reduce the dosage of 6MP if you give this drug concurrently

Answer 14

Allopurinol

Question 15

Drug that chelates iron and may protect against Doxorubicin cardio-toxicity

Answer 15

Dexrazoxane

Question 16

Drug that “blows” up DNA (breaks DNA strands); Pulmonary fibrosis is a limiting side effect

Answer 16

Bleomycin

Question 17

Drug that binds Tubulin; Prevents microtubule disassembly during the M phase, causing mitotic arrest

Answer 17

Paclitaxel [TAXOL]

Question 18

Anti-estrogen used for Estrogen Receptor + Breast Cancer

Answer 18

Tamoxifen

Question 19

Anti-emetics [used in association with anti-cancer drugs that are 5-HT3 (serotonin receptor subtype) antagonists]

Answer 19

Palonosetron
Dolasetron
Odansetron
Granisetron

“DOG, be a PAL. Don’t throw up.”

Question 20

Hormone that inhibits Prolactin release

Answer 20

Dopamine (DA)

Question 21

ACTH analog used for diagnosis of patients with corticosteroid abnormality

Answer 21

Co-syntropin

Question 22

Synthetic analog of ADH hormone used for Diabetes Insipidus and Nocturnal Enuresis

Answer 22

Desmopressin (DDAVP)

Question 23

DOC for tx: Hypothyroidism

Answer 23

Levo-Thyroxine [SYNTHROID]

Question 24

Thioamide that inhibits peripheral conversion of T4 to T3 in high doses (by inhibiting Thyroid Peroxidase); indicated for pregnant women in 1st trimester; less likely to cross placentaTx: Hyperthyroidism

Answer 24

Propyl-Thio-Uracil (PTU)

Question 25

Enzyme that is inhibited by Propyl-Thio-Uracil (PTU)

Answer 25

Thyroid Peroxidase