One Liners Set 06

Question 1

What receptors do Losartan and Valsartan block?

Answer 1

AT1 Receptors

Question 2

Side effect associated with ACEI but not ARBs

Answer 2

Dry cough

Question 3

Side effects of Calcium Channel Blockers (CCBs)

Answer 3

Constipation
Edema
Headache

Question 4

Effects of Beta Blockers

Answer 4

Reduce:
HR
Contractility
O2 Demand

Question 5

Cardio-selective Beta 1-blockers (3)

Answer 5

Acebutolol
Metoprolol
Atenolol

Question 6

Side Effects of beta blockers

Answer 6

Bradycardia
Increased TGs
Decreased HDLS
SEXUAL DYSFUNCTION

Question 7

Alpha 1selective blockers

Answer 7

Doxazosin
Prazosin
Terazosin

Question 8

A1a-selective blocker used for BPH

Answer 8

Tamsulosin [FLOMAX]

Question 9

Side Effects of alpha blockers

Answer 9

Orthostatic Hypotension (especially with 1st dose) 
Reflex Tachycardia

Question 10

Methyldopa is contraindicated in what population? Because?

Answer 10

Geriatrics d/t CNS Depression effects

Question 11

Notable Side Effect of Hydralazine

Answer 11

Lupus-Like Syndrome

Question 12

Diuretic used as prophylactic for mountain sickness and glaucoma

Answer 12

Acetazolamide (Carbonic Anhydrase Inhibitor)

Question 13

Side effects of acetazolamide

Answer 13

Metabolic acidosis
Hypokalemia
Paresthesias
Encephalopathy (in liver-impaired pts.)
Urine Alkalization (which may precipitate Ca2+ salts)

Question 14

Site of Action of loop diuretics

Answer 14

Thick Ascending Limb

Question 15

Side Effects of Loop Diuretics (e.g. Furosemide)

Answer 15

Metaboic alkaLosis
hypOkalemia
ototOxicity
hyPeruricemia

Question 16

An electrolyte that is lost in the urine by acute treatment with loop diuretics but can be retained by thiazides

Answer 16

Calcium

Question 17

Site of action of Thiazide Diuretics

Answer 17

Early Distal Convoluted Tubule

Question 18

Side effects of Thiazide diuretics (e.g. HCTZ)

Answer 18

Metabolic alkalosis
Hypokalemia
-------
Hyperglycemia
Hyperlipidemia
Hyperuricemia

Question 19

Mechanism of action of Amiloride

Answer 19

Inhibit epithelial Na+ channels in the DCTs and CTs

Question 20

Diuretics (2) used to treat Primary Aldosteronism

Answer 20

Spironolactone

Eplerenone

Question 21

Side effect of Spironolactone

Answer 21

Gynecomastia
Hyperkalemia
Impotence

Question 22

Diuretic used to reduce increased Intracranial Pressure

Answer 22

Mannitol

Question 23

MOA of antiarrhythmics:Class IA (e.g. Procainamide); Class IB (e.g. Lidocaine; Class IC (e.g. Flecainide)

Answer 23

Sodium channel blockers

Question 24

Side Effect of Procainamide

Answer 24

Lupus-like Syndrome

Question 25

Limiting side effect of Quinidine

Answer 25

Prolongs QT interval

Question 26

DOC for management of acute Ventricular arrhythmias

Answer 26

Lidocaine

Question 27

Life threatening cardiac event that prolonged QT leads to:

Answer 27

Torsades de Pointes

Question 28

MOA of Sildenafil (Viagra)

Answer 28

Inhibits phosphodiesterase-5 (PDE-5), | enhancing effects of nitric oxide-activated increases in cGMP

Question 29

MOA of Nitrates

Answer 29

``` Relax vascular smooth muscle Dilates Veins (at low doses) Dilates Arteries (at high doses) ```

Question 30

Heparin (PTT) increases activity of what?

Answer 30

Antithrombin III

Question 31

Common side effect of Aspirin

Answer 31

GI Bleeding

Question 32

MOA of thrombolytics

Answer 32

Catalyzes plasmin formation (which binds fibrin) lysing thrombi

Question 33

Thrombolytics are used for what?

Answer 33

DVTs | Pulmonary embolisms

Question 34

Agent affected in pernicious anemia

Answer 34

Cyanocobalamin (Vit B12)

Question 35

Agent used for treatment of megaloblastic anemia (but does NOT reverse neurologic symptoms) and also decreases neural tube defects during pregnancy

Answer 35

Folic acid

Question 36

Agent used for anemias associated with renal failure

Answer 36

Erythropoietin (EPO)

Question 37

How drug or foods (especially grapefruit juice) increase statin effect

Answer 37

By Inhibition of CYP 3A4

Question 38

Monitoring parameter to obtain before initiation of Statins

Answer 38

Liver Function Tests (LFT's)

Question 39

Drug that decreases liver triglycerol synthesis

Answer 39

Niacin

Question 40

Side Effect of Niacin

Answer 40

Flushing (cutaneous)

Question 41

Fibrates (gemfibrozil) increase activity of

Answer 41

Lipoprotein Lipase (LPL)

Question 42

Agent used for closure of Patent Ductus Arteriosus

Answer 42

Indomethacin

Question 43

Acetaminophen has what activities/effects?

Answer 43

Antipyretic | Analgesic activity

Question 44

DMARDs (Drug-Modifying Anti-Rheumatic Agents) are slow acting drugs for:

Answer 44

Rheumatic Disease

Question 45

Agents that inhibit xanthine oxidase and are used to treat chronic gout

Answer 45

Allopurinol Febuxostat ("Fubu, give me Xanthine Oxidase, STAT!"