Other anterior pituitary hormones Flashcards Preview

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Flashcards in Other anterior pituitary hormones Deck (19):
1

Glucocorticoids

cortisol, involved in normal metabolism and response to stress

2

Mineralcorticoids

aldosterone, responsible for maintaining salt and water metabolism

3

Glucocorticoid effects

promote normal intermediary metabolism, increase resistance to stress, alter blood cell levels in plasma, anti-inflammatory action

4

What are the uses of glucocorticoid use?

replacement therapy for adrenocortical insufficiency, diagnose, cushings, replacement therapy for congenital adrenal hyperplasia, relief of inflammatoy sx, treat allergies, accelerate lung maturation

5

Mineralcorticoid effects

aldosterone acts on kidney tubules/collecting ducts, inc reabsorption of sodium, bicarb, and h2o, dec reabsorption of K

6

What does spironolactone do?

inhibits sodium reabsorption in the kidney, used to treat hyperaldosteronism, also for HTN, and can antagonize aldosterone and testosterone synthesis

7

the release of growth hormone

highest level during sleep, release decrease with increasing age, decrease lean muscle, promotes cell proliferation and bone growth

8

Uses of somatotropin

GH deficiency or growth failure in children, AIDs wasting syndrome, short bowel syndrome, replacement in adults with confirmed GH deficiency, illegal use as performance enhancing drugs

9

GnRH drugs

leuprolide (Lupron), Goserelin (Zoladex)

10

MOA of gonadotropin releasing hormone

agonist at GnRH receptor-suppress production of gonadal hormones when given continuously

11

Clinical use of gonadotropin releasing hormone

treatment of prostatic cancer, endometriosis and precocious puberty, prostate cancer, breast cancer, endometriosis

12

Male gonadotropins

testosterone, androstenedione, dihydrotestosterone

13

female gonadotropins

estradiol, estriol, estrone, progesterone

14

Oxytocin (Pitocin) MOA

stimulates uterine contractions, induce or reinforce labor, sensitivity of uterus to oxytocin increases with duration of pregnancy

15

Oxytocin adrs

hn, uterine rupture, water retention and fetal death, contraindicated in abnormal fetal presentation, fetal distress and premature birth

16

Vasopressin MOA

binds V2 receptor in kidney- increase water permeability and reabsorption, binds V1 receptor- vasoconstriction, inotropic stimulation

17

When would V2 binding be necessary

diabetes insipidus

18

toxicities of vasopressin

H2O intoxication and hyponatremia, headache, bronchoconstriction and tremor

19

Desmopressin pearls

modified vasopressin, minimal V1 activity, preferred for diabetes insipidus and nocturnal enuresis, intranasal or oral administration, intranasal not for nocturnal enuresis