Sympatholytics Flashcards Preview

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Flashcards in Sympatholytics Deck (28):
1

Sympatholytics can be

Receptor selective or non-selective, full antagonists or partial, reversible or irreversible

2

Sympatholytics primarily cover two classes of drugs

beta blockers and alpha blockers

3

Alpha blockers include

Phentolamine (regitine), Doxazosin (cardura), prazosin (minipres), Tterazosin (hytrin), Tamsulosin (flomax), Silodosin (Rapaflo), Alfuzosin (uroxatral)

4

B1 selective blockers include

acebutolol (sectral), Atenolol (tenormin), bisoprolol (zabeta), esmolol (brevibloc), Metoprolol (lopressor, Toprol), Nebivolol (bystolic)

5

B1 nonselective blockers include

carvedilol (coreg), labetolol (normodyne), nadolol (Corgard), propranolol (Inderal), Sotalol (Betapace)

6

B1 nonselective blockers include

carvedilol (coreg), labetolol (normodyne), nadolol (Corgard), propranolol (Inderal), Sotalol (Betapace)

7

Phentolamine (regitine)

alpha, only non-selective alpha blocker, IV, short acting, vasodilator, induced tachycardia (problem),

8

Doxazosin (cardura)

vasodilator, alpha1, hypertension, also BPH*, 20 hour half life, once daily, most common, dose titration necessary

9

Terazosin (hytrin)

vasodilator, alpha1, hypertension, also BPH*, 12 hour half life, dose titration necessary

10

Prazosin (minipres)

vasodilator, alpha1, hypertension, also BPH*, 3 hour half life, once daily, dose titration necessary

11

What carries risk for exacperating BPH

benztropine

12

Alfuzosin (Uroxatral)

uroselective a1, limited use, orthostatic HTN

13

Tamsulosin (Flomax)

a1, BPH, no dose adjust, no dose titration

14

Silodosin (Rapaflo)

a1, adjust renal, BPH, me too, $$$$

15

Ergot alkaloids

old, a1, LSD derivative, migraines, not clean, can induce labor, limited use

16

One of the most well studied and used drug class?

beta blockers

17

uses of beta blockers

HTN, CHF, MI, migraines, arrythmias, CAD, glaucoma, stage fright, PTSD, tremor, etc

18

Beta blocker info

competative antagonist, non-selective, or cardioselective, impact on renin release, variable lipid solubility, can act as partial agonist

19

Well-known ADR of beta blockers

bradycardia, AV blockade, compromised CO, masks symptoms of hypoglycemia, tachy

20

Well-known ADR of beta blockers

bradycardia, AV blockade, compromised CO, masks symptoms of hypoglycemia, tachy

21

Propranolol (Inderal)

non selective B1, B2, short acting, lipophiilic, DOC for stage fright, migraine, PTSD, and variceal bleeding, old, cheap

22

Nadolol (Corgard)

nonselective B1, B2, longer acting, no niche

23

Sotalol (betapace)

non-selective B1, B2, arrythymias, must adjust renal, only used when necessary because of adrs

24

Labetalol (Normodyne)

non-slective a1, B1. B2, acute HTN emergency, vasodilation (a1), little ADR but ortho hypotension, DOC for HTN w/ acute ischemic stroke and pregnant/ labor

25

Carvedilol (coreg)

non-slective a1, B1, B2, CHF, slow progression of disease by acting on RAAS

26

Metoprolol (lopressor, toprol)

succinate (toprol): long acting, tartrate (lopressor) short acting; selective B1, CHF, most common beta blocker

27

Atenolol (tenormin)

selective B1, longer acting, no evidence to support CHF

28

Bisoprolol (zebeta)

Selective B1, some use with CHF, not much