P14 - GI Part 1

Question 1

appetite stimulants MOA

Answer 1

• increase GABA

- decrease serotonin

Question 2

which appetite stimulant is for cats

Answer 2

• cyproheptadine

Question 3

appetite stimulant drugs (4)

Answer 3

• benzodiazepines
• cyptoheptadine
• glucocorticoids & vit B
• anabolic steroids

Question 4

appetite suppressants MOA

Answer 4

• inhibit fat absorption

Question 5

appetite suppressants drugs (1)

Answer 5

• dirlotapide (Slentrol)

Question 6

dirlotapide (appetite suppressant) is not used when (2)

Answer 6

• in cats

- in dogs with liver disease, Cushing’s or corticosertoids

Question 7

5 control centers of emetics (vomiting)

Answer 7

• CTZ
• vestibular system
• peripheral sensory
• neurotransmission from higher CNS
• substance P

Question 8

peripherally acting emetics MOA

Answer 8

• irritates mucosa

Question 9

peripherally acting emetics drugs (3)

Answer 9

• warm salt water
• hydrogen peroxide
• ipecac

Question 10

which peripherally acting emetic due used cautiously in cats

Answer 10

• ipecac

Question 11

centrally acting emetics MOA

Answer 11

• stimulates CTZ

Question 12

centrally acting emetics drugs (2) and for what species

Answer 12

• apmonphine hydrochloride - dog

- xylazine - cats

Question 13

xylazine side effect

Answer 13

• brachycardia

Question 14

centrally acting anti-emetics groups (4)

Answer 14

• anti-histaminergics
• anti-muscarinics
• anti-dopaminergics
• NK-1 receptor antagonists

Question 15

centrally acting anti-emetics MOA

Answer 15

• blocks at higher CNS and at emetic center

Question 16

anti-histaminergics (anti-emetics) MOA

Answer 16

• blocks H1 receptors at vestibular apparatur

Question 17

anti-histaminergics (anti-emetics) drugs (3)

Answer 17

• cyclizine hydrochloride
• dimenhydrinate
• diphenhydramine

Question 18

anti-histaminergics (anti-emetics) side effects

Answer 18

• sedation

Question 19

anti-muscarinics (anti-emetics) MOA

Answer 19

• stop M1 and ACh

Question 20

anti-muscarinics (anti-emetics) drugs (2)

Answer 20

• atropine

- scopolamine

Question 21

T/F: scopolamine can penetrate the BBB

Answer 21

• true

Question 22

anti-muscarinics (anti-emetics) side effects

Answer 22

• drowsiness
• constipation
• urinary retention

Question 23

anti-muscarinics (anti-emetics) used for

Answer 23

• controlling motion sickness in dogs

Question 24

anti-dopaminergics (anti-emetics) MOA

Answer 24

• acting at CTZ

Question 25

anti-dopaminergics (anti-emetics) drugs (4)

Answer 25

- phenothiazine derivatives - butyrophenones - metoclopramide - 5-HT3 serotonin antagonists

Question 26

which anti-dopaminergics (anti-emetics) is broadest spectrum

Answer 26

- phenothiazine derivatives

Question 27

phenothiazine derivatives contra indicated in

Answer 27

- animals with seizures or dehydrated

Question 28

which anti-dopaminergics (anti-emetics) is most potent

Answer 28

- metoclopramide

Question 29

in which species does metoclopramide cause hyperactivity and excitability

Answer 29

- horses and cats

Question 30

which anti-dopaminergics is used for patents on chemo drugs

Answer 30

- ondonsetron

Question 31

NK-1 receptor antagonists MOA

Answer 31

- blocks sup P in CNS

Question 32

NK-1 receptor antagonists (anti-emetics) drugs (1)

Answer 32

- maropitant citrate (cerenia)

Question 33

NK-1 receptor antagonists used for

Answer 33

- motion sickness in dogs

Question 34

side effects of NK-1 receptor antagonists

Answer 34

- bone marrow hypocellularity in young puppies

Question 35

peripherally acting anti-emetics MOA

Answer 35

- protect GI from irritation

Question 36

peripherally acting anti-emetics drugs (3)

Answer 36

- anti-cholinergics - metocloprimide - domperidone

Question 37

side effects of peripherally acting anti-emetics

Answer 37

- delays gastric emptying

Question 38

group of drugs that decrease gastric acid secretion (4)

Answer 38

- anti-cholinergics - H2 receptor antagonist - proton pump inhibitors - prostaglandin E analogue

Question 39

anti-cholinergics MOA

Answer 39

- acts on M1 receptor

Question 40

anti-cholinergics drug for decrease gastric acid secretion

Answer 40

- pirenzepine

Question 41

H2 receptor antagonists drugs for decreasing gastric acid secretion (4)

Answer 41

- cimetidine - ranitidine - famotidine - nizatidine

Question 42

which H2 receptor antagonist has an immune-modulatory effect (T-cells)

Answer 42

- cimetidine

Question 43

which H2 receptor antagonist is most potent

Answer 43

- famotidine

Question 44

side effects of H2 receptor antagonists that are decreasing gastric acid secretion

Answer 44

- rebound hyperexcretion | - relapse of gastric ulcers

Question 45

T/F: proton pump inhibitors are irreversible

Answer 45

- true

Question 46

proton pump inhibitors drugs for decreasing gastric acid secretion

Answer 46

- omeprazole

Question 47

which class of drugs is aspiration pneumonia in dog with megaesophagous a side effect

Answer 47

- proton pump inhibitors (omeprazole)

Question 48

prostaglandin E analogue MOA

Answer 48

- decrease cAMP -> decreases gastric acid | - increase mucous & bicarb secretion

Question 49

prostaglandin E analogue drug

Answer 49

- misoprostol

Question 50

which drug has no rebound hyperexcretion and is used to decrease gastric acid secretion

Answer 50

misoprostol

Question 51

side effects of misoprostol

Answer 51

- diarrhea | - uterine contraction