P15 - GI Part 2

Question 1

cytoprotective drugs classes (4)

Answer 1

• antacids
• prostaglandin E1 analog
• sucralfate
• bismuth subsalicylate

Question 2

antacids MOA

Answer 2

• bases that react with HCL -> insoluble colloid & H2O

Question 3

non-systemic antacids drugs (2)

Answer 3

• aluminum hydroxide

- magnesium hydroxide

Question 4

systemic antacids drugs (1)

Answer 4

• sodium bicarbonate

Question 5

side effect of sodium bicarbonate

Answer 5

• bloat

Question 6

prostaglandin E1 analog MOA

Answer 6

• increase mucus & bicarb

- stabilizes mast cells

Question 7

prostaglandin E1 analog drugs

Answer 7

• misoprostol

Question 8

sucralfate MOA

Answer 8

• protect ulcer tissue from acid, bile and pepsin

Question 9

side effects of sucralfate

Answer 9

• decreases oral bioavability of other drugs

Question 10

sucralfate requires what type of environment

Answer 10

• acidic

Question 11

bismuth MOA

Answer 11

• absorbs E. coli entertoxins

Question 12

salicylate MOA

Answer 12

• decrease intestinal secretions

- anti-inflammatory

Question 13

salicylate is used cautiously in what species and why

Answer 13

• cats

- glucorconidation

Question 14

classes of drugs that increase GI motility (2)

Answer 14

• cholinergic agonists

- prokinetic agents

Question 15

cholinergic agonists MOA

Answer 15

• agonist on ACh receptors

- for GI muscle atony

Question 16

cholinergic agonists drugs (2)

Answer 16

• bethanechol

- carbachol

Question 17

cholinergic agonists side effects

Answer 17

• cramps
• diarrhea
• salivation
• bradycardia

Question 18

cholinergic agonists are contra indicated for

Answer 18

• obstructions

- peritonitis

Question 19

prokinetic agents MOA

Answer 19

• increase ACh

- block dopamine

Question 20

prokinetic agents drugs (3)

Answer 20

• metoclopramide
• cisapride
• domperidone

Question 21

cisapride spectrum and specific use

Answer 21

• broad spectrum

- for megacolon in cats

Question 22

classes of drugs that decrease intestinal motility and secretions (2)

Answer 22

• anti-cholinergics

- opioid agonists

Question 23

anti-cholinergics MOA

Answer 23

• inhibit ACh

Question 24

anti-cholinergics drugs (2)

Answer 24

• atropine

- scopolamine

Question 25

clinical indications of anti-cholinergic drugs

Answer 25

- diarrhea in calves | - mild colic

Question 26

anti-cholinergics combined with NSAIDs effect

Answer 26

- clear smooth muscle spasm

Question 27

opioid agonists MOA -

Answer 27

- inhibit ACh and choline receptors

Question 28

opioid drugs (4)

Answer 28

- morphine - fentanyl - meperidine - paregotic

Question 29

meperidine drugs (2)

Answer 29

- diphenoxylate (difenoxin) | - loperamide

Question 30

cat that ODs on diphenoxylate signs

Answer 30

- neurological signs

Question 31

paregotic is used in what species

Answer 31

- foals

Question 32

opioid agonists are indicated for what

Answer 32

- non-specific acute & chronic diarrhea

Question 33

opioid agonists are contra indicated for what

Answer 33

- diarrhea due to infectious causes

Question 34

anti-diarrheal drugs for cats

Answer 34

- propantheline - loperamide hydrochloride caspsules - bismuth subsalicylate suspension

Question 35

GI protectants and absorbents MOA

Answer 35

- line GI and precent irritation

Question 36

GI protectants and absorbents drug

Answer 36

- bismuth subsalicylate - activated charcoal - cholestyramine - kaolin - pectin

Question 37

bismuth subsalicylate absorbs

Answer 37

- E. coli enterotoxins

Question 38

activated charcoal is used for

Answer 38

- emergency treatment

Question 39

cholestyramine is used for

Answer 39

- hyperchotesterolemia

Question 40

side effects of cholestyramine

Answer 40

- nausea - constipation - decrease absorption of fat soluble vitamins

Question 41

kaolin and pectin are used for

Answer 41

- non-specific diarrhea