P20 - Antiprotozal

Question 1

treatment of giardiasis with MOA of DNA damage (3); and which one can be carcinogenic

Answer 1

• metronidazole - can be carcinogenic
• tinidazole
• ipronidazole

Question 2

treatment of giardiasis with MOA of interaction with B-tubulin (2)

Answer 2

• fenbendazole -> prodrug fenbental - 1st choice

- albendazole

Question 3

treatment of giardiasis with MOA interference with cell membrane (1)

Answer 3

• quinacrine (used for resistant)

Question 4

treatment of giardiasis with MOA of production of free radicals (1)

Answer 4

• furazolidone

Question 5

treatment of leishmaniasis 1st line drugs (4)

Answer 5

• allopurinol
• meglumine antimonate
• sodium stibogluconate
• amphotericin B

Question 6

allopurinol MOA

Answer 6

• prevents uric acid

Question 7

treatment of leishmaniasis 2nd line drugs (3)

Answer 7

• metronidazole with enrofloxacin
• paromomycin
• ketoconazole

Question 8

paromomycin MOA

Answer 8

• inhibit protein synthesis at 30s

Question 9

sulphonamides MOA

Answer 9

• inhibition of early steps in folate synthesis

Question 10

diaminopyrimidines combined with sulphonamides (2)

Answer 10

• trimethoprim

- ormetoprim

Question 11

treatment of coccidiosis MOA thiamine analogue (2)

Answer 11

• amprolium

- amprolium-sulfadimethoxine

Question 12

treatment of coccidiosis MOA oxygen free radicals (1)

Answer 12

• furazolidone

Question 13

treatment of coccidiosis MOA apicoplast interactions (1)

Answer 13

• ponazuril

Question 14

treatment of coccidiosis MOA folic acid synthesis (2)

Answer 14

• sulfadimethoxine

- trimethoprim-sulfonamide

Question 15

treatment of coccidiosis that is used in dogs only (1)

Answer 15

• amprolium-sulfadimethoxine

Question 16

treatment of coccidiosis in chickens

Answer 16

• polyether ionophores

Question 17

polyether ionophores MOA

Answer 17

• form lipophilic complexes with alkali metal cations

- changes in membrane integrity and internal osmolality

Question 18

polyether ionophores drugs (5)

Answer 18

• lasalocid
• maduramicin
• monensin
• narasin
• salanomycin

Question 19

which polyether ionophores are used in broilers and rearing (2)

Answer 19

• monensin

- salanomycin

Question 20

side effects of polyether ionophores

Answer 20

• cardiovascular effects due to increase Ca

Question 21

highly susceptible species of side effects of polyether ionophores

Answer 21

• equids

- guinea fowl

Question 22

T/F: polyether ionophores can develop resistance

Answer 22

• true

Question 23

drugs against sarcocystis neurona (2)

Answer 23

• triazine derivatives

- nitrothiazole derivatives

Question 24

triazine derivatives MOA

Answer 24

• act on apicoplast

Question 25

triazine derivatives drugs (3)

Answer 25

- diclazuril - toltrazuril - ponazuril (active metabolite)

Question 26

which triazine derivative due sodium salt increases its bioavability

Answer 26

- diclazuril

Question 27

treatment of piroplasmosis (2)

Answer 27

- imidocarb dipropionate | - naphtoquinones (parvaquone and buparvaquone)

Question 28

which drug is not approved for cattle but is used to treat canine babesiosis

Answer 28

- imidocarb dipropionate

Question 29

which drug is approved for treatment of theilerosis in wild ruminants in the US and domestic in Europe

Answer 29

- naphtoquinones (parvaquone & buparvaquone)