P27 - CSF Fluid Flashcards Preview

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Flashcards in P27 - CSF Fluid Deck (24)
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1
Q

purpose of analysis of CSF

A
  • evaluation of neurologic disease
2
Q

CSF flows in what direction

A
  • cranial to caudal
3
Q

CSF must be analyzed within ___ of collection

A
  • 1 hour
4
Q

what tube is preferred for CSF collection

A
  • red top
5
Q

problems with EDTA for CSF collection (3)

A
  • increases protein concentration
  • causes cell lysis
  • dilutes TNCC and protein in small samples
6
Q

what is added to stabilize CSF sample

A
  • BSA or fetal calf serum
7
Q

what is measured before BSA or fetal calf serum is added to CSF and why

A
  • protein

- serum is rich in protein

8
Q

laboratory findings in normal CSF (5)

A
  • colorless
  • transparent
  • water-like
  • low protein
  • low TNCC
9
Q

xanthochromia

A
  • presence of hemoglobin in CSF

- pinkish to orange to yellowish color

10
Q

hematorrhachis

A
  • hemorrhage in vertebral column

- pinkish-red to orange discoloration

11
Q

bilirrhachia

A
  • hemoglobin present for 2 days

- bilirubin

12
Q

turbidity/pleocytosis of CSF

A
  • high TNCC
13
Q

causes of pleocytosis

A
  • inflammation and microorganisms
  • neoplasia
  • hemorrhage
14
Q

horses have higher concentrations of what in CSF

A
  • proteins - 80mg/dl
15
Q

gel or clot formation of CSF is indicative of

A
  • inflammation
16
Q

where does CSF have higher protein concentrations and why

A
  • lumbosacral samples

- more water removed

17
Q

effects of drop of blood contamination of CSF on RBC, TNCC, and protein

A
  • increases RBC by 12,000/uL
  • increases TNCC by 200/uL
  • increases protein by 100mg/dl
18
Q

cytologic/albuminocytologic dissociation

A
  • high protein without a corresponding increase in TNCC
19
Q

causes of cytologic/albuminocytologic dissociation

A
  • compression from space occupying lesion
  • pathology deep in parenchyma and can’t reach CSF
  • BBB pathologic cells not superficial enough to slough into CSF
20
Q

further unique CSF tests (3)

A
  • [glucose]
  • creatine kinase
  • antibody titers
21
Q

hypoglycorrhacia and causes

A
  • low CSF glucose
  • utilized by bacteria in CSF, inflammatory cells, RBC
  • hypoglycemia
22
Q

hyperglycorrhacia and causes

A
  • high CSF glucose
  • hyperglycemia
  • increase permeability of BBB
23
Q

[CSF glucose] is about what % of [plasma glucose]

A
  • 60-80%
24
Q

what is increased in case of damage to nerve cells

A
  • creatine kinase