Parvoviridae Flashcards

(48 cards)

1
Q

Describe the genome of Parvoviridae

A

linear SSDNA

nonenveloped (which is why parvo survives so well in the environment)

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2
Q

What are the 2 subfamilies of Parvoviridae?

A
  • ParvoviriNae*
  • Densovirinae (infects insects)*
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3
Q

What are the 5 genuses of Parvovirinae**?

A
  • Parvovirus*
  • Erythrovirus*
  • Bocavirus*
  • Dependovirus*
  • Amdovirus*

BAPED

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4
Q

Parvoviruses replicate in the _________

A

nucleus

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5
Q

T/F:

Parvoviridae infection will show large intranuclear inclusion bodies

A

TRUE

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6
Q

T/F:

Parvoviruses can replicate in stationary cells

A

FALSE!

Parvoviruses can only replicate in DIVIDING cells

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7
Q

Genus Parvovirus includes what 3 viruses?

A

Feline Panleukopenia

Canine Parvovirus

Porcine Parvovirus

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8
Q

Genus Erythrovirus includes what diseases?

A

Fifth Disease

Slap Cheek Rash

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9
Q

Goose and duck parvoviruses, and sometimes bovine parvovirus 2 are included in what genus of Parvoviridae?

A

Genus Dependovirus

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10
Q

This genus of virus is unique because it contains a 3rd orf (open reading frame).

They usually infect the GI and Respiratory tracts and are found in humans, dogs, and cattle.

A

Genus Bocaviruses

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11
Q

Which genus includes human parvovirus B19

which causes a mild rash illness and aplastic anemia in children along with painful joints.

It is NOT zoonotic.

A

Genus Erythrovirus

(Fifth disease and Slap Cheek Rash)

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12
Q

Viruses of this genus are unable to replicate and do not cause disease.

A

Genus Dependovirus

because it DEPENDS on a helper virus, usually adenoviridae

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13
Q

Feline parvovirus causes Feline Panleukopenia (FPV)

what are 2 synonyms for it?

A

Feline distemper

Feline infectious enteritis

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14
Q

Cats can shed FPV in their urine and feces for ___ weeks after recovery

A

6 weeks!

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15
Q

How can cats contract Feline Panleukopenia (FPV or Feline Parvovirus)?

A

Oro-nasally

In-utero

Mechanically via flies

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16
Q

What is the hallmark of Feline Parvovirus that causes profound destruction of all white blood cell elements both in circulation or in lymphoid tissues?

A

Panleukopenia

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17
Q

Feline Panleukopenia (FPV or Feline Parvovirus)

selectively damages replicating cells in the _______ of the intestinal mucosa

A

crypts

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18
Q

What is the result of damge to intestinal crypt epithelium caused by

Feline Panleukopenia (FPV or Feline Parvovirus)?

A

Villous Collapse

Enteritis

Diarrhea

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19
Q

What is the result of damage to Lymph Node and Thymus cells

caused by

Feline Panleukopenia (FPV or Feline Parvovirus)?

A

Germinal center depletion

Apoptosis of lymphocytes

Thymic atrophy

Lymphopenia

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20
Q

What is the result of damage to bone marrow caused by

Feline Panleukopenia (FPV or Feline Parvovirus)?

A

stem cell depletion

Neutropenia–>Thrombocytopenia–>Anemia

21
Q

What is the result of damage to a fetus caused by

Feline Panleukopenia (FPV or Feline Parvovirus)?

A

Loss of pregnancy

22
Q

T/F:

Feline Panleukopenia (FPV or Feline Parvovirus)

can affect the cerebellum of cats.

A

TRUE!!

It can cause cerebellar hypoplasia and eventually cerebellar ataxia

23
Q

In-utero *Feline Panleukopenia (FPV or Feline Parvovirus) *infection can cause

this in kittens whose mother was infected during early fetal development

A

Optic Nerve hypoplasia

24
Q

When does a mother cat have to be infected with Feline Panleukopenia (FPV or Feline Parvovirus)

in order for cerebellar hypoplasia to occur?

A

During the last 2 weeks of pregnancy

25
In addition to cerebellar hypoplasia, what other CNS disease can a cat infected with *Feline Panleukopenia (FPV or Feline Parvovirus)* have?
Hydraencephaly
26
Kittens with *Feline Panleukopenia (FPV or Feline Parvovirus)* are also susceptible to \_\_\_\_\_\_\_\_\_
_secondary bacterial infections_
27
T/F: Disseminated Intravascular Coagulation DIC is a characteristic of *Feline Panleukopenia (FPV or Feline Parvovirus)*
TRUE
28
T/F: A modified-live virus is safe and effective for all cats infected with *Feline Panleukopenia (FPV or Feline Parvovirus)*
FALSE! YOU SHOULD NEVER GIVE AN MLV TO: Pregnant, immunosuppressed, sick cats or kittens less than 4 weeks old
29
The first vaccination for kittens against *Feline Panleukopenia (FPV or Feline Parvovirus)* is at **6 - 9 weeks old**. The last dose of the initial vaccine should be given *after* the kitten is \_\_\_\_\_\_\_ weeks old, as to not mess with the maternal antibodies
_16 weeks old_
30
T/F: Canine Parvovirus 1 is the severe form of *Parvovirus *in dogs and very deadly
FALSE!!! *Canine Parvovirus **2** *is the deadly one
31
What are the 3 antigenic variants of *Canine Parvovirus 2*?
CPV 2a CPV 2b CPV 2c 2b and 2c are found in America!
32
Clinically, 3 age related syndromes have been recognized as associated with *Canine Parvovirus 2* Days 2-12 causes ____________ and is **uncommon**
_generalized neonatal disease_
33
Clinically, 3 age related syndromes have been recognized as associated with Canine Parvovirus 2 **Age 3 - 8 weeks** causes \_\_\_\_\_\_\_\_\_\_
_Myocarditis_
34
Clinically, 3 age related syndromes have been recognized as associated with Canine Parvovirus 2 **Ages 2 - 4 months **causes _________ and ________ and is the **most common**
_enteritis_ and _panleukopenia_
35
T/F: Serology is a good method for testing for *Canine Parvovirus 2*
FALSE!!! Serology sucks for *Canine Parvovirus 2* Use a **SNAP test for parvo** instead!
36
When should the first round of shots be given to prevent puppies from getting ## Footnote *Canine Parvovirus 2?*
7 weeks 11 weeks 15 weeks Booster after 1 year Every 3 years after the booster
37
T/F: Oseltamivir has been shown to reduce symptoms of *Parvovirus* *Feline Panleukopenia Virus (**FPV)* and *Canine Parvovirus 2*
TRUE!
38
What is an infectious cause of reproductive failure causing SMEDI in swine throughout the world?
*Porcine Parvovirus*
39
T/F: Death at different stages of pregnancy is typical of *Porcine Parvovirus*
TRUE
40
What is the **HALLMARK of *Porcine Parvovirus*?**
The increase in mummified fetuses after a **normal gestation** period
41
T/F: Abortions are a common symptoms of pigs infected with *Porcine Parvovirus*
FALSE!! ## Footnote **ABORTIONS are NOT common**
42
In *Porcine Parvovirus*, time of infection is CRITICAL. What happens if a sow is infected in the **first 30 days** of gestation?
The fetus dies and is reabsorbed
43
In Porcine Parvovirus, time of infection is CRITICAL. What happens if a sow is infected between **30 - 70 days **into gestation?
Fetuses die and become mummified
44
In Porcine Parvovirus, time of infection is CRITICAL. What happens if a sow is infected **After 70 days** of gestation?
late fetuses develop lesions but also mount immune response and survive in-utero
45
T/F: Although uncommon, pigs infected with *Porcine Parvovirus* can suffer from respiratory tract diseases and vesicular diseases
TRUE!
46
T/F: Serological tests are useful in diagnosing *Porcine Parvovirus*
FALSE Serology is USELESS in diagnosis of *Porcine Parvovirus*
47
Unlike most parvoviruses, *Porcine parvovirus* can cause _______ infections with ________ shedding
*Porcine parvovirus* can cause _persistent_ infections with _periodical_ sheddiing
48
What is the **best way** to prevent *Porcine Parvovirus?*
Vaccinate all susceptible breeding stock **twice, 2 weeks apart, several weeks before breeding**