Path of Infectious and non-infectious inflammatory disease Flashcards Preview

Pulmonology 2 > Path of Infectious and non-infectious inflammatory disease > Flashcards

Flashcards in Path of Infectious and non-infectious inflammatory disease Deck (17):
1

What are the different types of Pneumonia?

Acute:Pyogenic with neutrophils in alveoli
Pneumonitis: not pyogenic "atypical"
Chronic: TB, Fungi, parasites, Odd bacteria(nocardia, actinomyces)

2

What factors predispose to Pneumonia?

Dec Cough Reflex?
injury to mucocilliary escaltor
Dec immunity of alveolar macrophages
Pulm edema
Accumulated secretions

3

What are the different pneumonia syndromes?

Community acquired Acute
Community acquired Atypical
Nosocomial
Aspiration
Chronic Pneumonias
Necrotizing pneumonias and lung abcess
Immunocompromized

4

What causes consolidation in pneumonia?

Alveoli filled with inflammatory exudate.

5

What are the different morphologies of pneumonia?

Broncho-pneumonia (more diffuse)
Lobar Pneumnia: dense in a single lobe (hear rales)

6

What is the gross appearance of Pneumonia?

Dispersed elevated 3-4cm lesions of palpable consolidation
Filled with neutrophils

7

What causes the majority of Lobar Pneumonia?

Strep Pneumo

8

What are the classic stages of Pneumonia?

Congestion
Red Hepatization
Gray Hepatization
Resolution

9

What are the compications of Bacterial Pneumonia?

Abcess
Empyema
Org of exudate with fibrosis
Bacteremic dissemination to Heart valves, brain, etc
Pleuritis
Pleural Effusion
Bronchopleural fistula

10

What is Community Acquired Atypical Pneumonia?

Lack of alveolar exudate
Inc WBCs
Acute febrile respiratory disease
Largely confined to alveolar septa and interstitium
Mycoplasma
Chlamidia

11

What is the common presentation of 1^ atypical Pneumonia?

Like common cold or LRI with lots of nasal discharge and pharyngitis
Sputum changes to green or yellow
Spontaneous res(or with erythromycin)

12

What are the immune mediators that cause sarcoidosis?

CD4+ Th1 cells
Increased cytokines IL-2 and IFN-gamma
Inc IL-8 and TNF lead to recruitment of addl T cells and monocytes which leads to Granulomas

13

What is seen in granulomas in Sarcoidosis?

Schaumann Bodies: Lamellated calcified structures with giant cells.
Asteroid bodies: Star shaped eosinophilic bodies made of compressed intermediate filaments

14

What is Acute vs Chronic Hypersensitivity Pneumonitis?

Acute: Large exposure to antigen => severe dyspnea, cough, high fever and chills
Chronic: Prolonged exposure to small amounts of antigen => dyspnea, cough and fatigue, resp failure

15

What are the most common types of Hypersensitivity Pneumonitis?

Farmer's Lung: thermophilic actinomyces in hay
Pigeon Breeder's lung
Humidifier of AC lung

16

What is the interstitial inflammatory disease caused by SMoking?

Desquamative Intersitial Pneumonia
Increased levels of macrophages
TII Pneumocyte hyperplasia

17

What is the cause of Pulmonary Alveolar Proteinosis?

Increased production of Surfactant
Acellular
Cough up chunks of white, gellatinous substance