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Hugh's MD2 Foundation > Pathology > Flashcards

Flashcards in Pathology Deck (13):
1

What happens to K levels in erroneously haemolysed blood?

It increases

2

What is APTT?

Activated partial thromboplastin time

3

HER2 amplification can be found in which type of cancer?

Breast

4

BRAF mutation can be found in which type of cancer?

Melanoma

5

6

Which liver enzymes are cytoplasmic?

AST, ALT, LD

7

Which liver enzymes are membrane bound?

ALP, GGT

8

Which liver enzymes are in the mitochondria?

Mitochondrial AST

9

What does enzyme induction refer to in regards to liver function tests?

Some drugs or alcohol induce increased production of liver enzymes causing elevated LFTs when only normal cell turnover is occurring

Eg Raised GGT due to alcohol induction

10

Which is liver specific, ALT or AST?

ALT - think L for liver

11

Which has a shorter half life, AST or ALT?

What are the implications?

AST is shorter (36hrs 

 to 12hrs) therefore, will be gone faster than ALT

There is more AST than ALT so AST will be higher early on

12

Normal ALT in hep A infection?

2500-5000

13

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