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Y1 Cardiovascular > Pathology > Flashcards

Flashcards in Pathology Deck (50)
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1

A clot is...

when blood clots outside a vessel - becomes a bruise

2

Pathway of activated factors in intrinsic pathway?

XII > XI > IX + VIIIa > common pathway

3

Warfarin competes with...

Vitamin K

4

V and VIII are degraded by?

protein C and S

5

Vitamin K is required for which factors? (4)

II, VII, IX and X

6

Vitamin K is required for which factors? (4)

II, VII, IX and X

7

Main anti-clotting proteins

Protein C, protein S and anti-thrombin III

8

II, IX and X are degraded by ?

anti-thrombin III

9

Activated partial thromboplastin time used to measure

the extrinsic pathway

10

Why is stasis an issue?

allows coagulants to slow down and increase contact with each other

11

Glycoproteins IIb and IIIa bind...

fibrinogen

12

Anti-thrombin III degrades

II, IX and X

13

Protein C, protein S and anti-thrombin III are...

main anti-clotting proteins

14

What factors do activated platelets release to attract other platelets? (4)

vWF, platelet activating factor, thromboxane A2, ADP

15

when might thrombosis occur in the arterial system?

where there is atherosclerosis where there might be plaque rupture

16

XII > XI > IX + VIIIa > common pathway is the starting point of which coagulation cascade?

intrinsic pathway

17

Vitamin K is...

fat soluble vitamin stored in the liver

18

Where does turbulence normally occur?

at the bifurcation of the artery

19

What relevance has Poiseuilles Law on the formation of thrombosis?

a small change in vessel radius will have a large effect on flow in the vessel

20

Instrinsic pathway is measured by...

pro-thrombin time

21

What is the main natural clot buster?

plasmin

22

Intrinsic pathway starts with Hageman factor XII and?

Kalikrien

23

Protein C and S degrade

V and VIII

24

Tissue factor --> Tissue factor and VII > common pathway are part of which coagulation cascade?

extrinsic pathway

25

pro-thrombin time is used to measure

the intrinsic pathway function

26

Warfarin overdose can be corrected with...

Vitamin K

27

Start of the extrinsic pathway is...

Tissue factor --> Tissue factor and VII > common pathway

28

Infarction is...

death of a tissue as a result of ischaemia

29

Factor V Lieden disorder?

point mutation in factor V where it would normally be targeted by protein C and S

30

Thrombosis is...

a blood clot within a vessel